High-throughput screening led to the identification of a 3-norbornyl derivative of catechol called 48F10 (3-bicyclo[2.2.1]hept-2-yl-benzene-1,2-diol) as a Kv2.1 K(+) channel inhibitor. By virtue of the involvement of Kv2.1 channels in programmed cell death, 48F10 prevents apoptosis in cortical neurons and enterocytes. This uncharged compound acts with an apparent affinity of 1 muM at the tetrae...

A novel analytical procedure has been developed for the analysis of ultra trace levels of 1,2-dichloroethane (EDC) in air using sample enrichment in combination with micromachined gas chromatography (GC) and differential mobility detection (DMD). When compared to other contemporary GC techniques, such as GC-flame ionization detection, GC-electron capture detection, or GC-electrolytic conductivi...

A study of gas transport properties of novel polynorbornenes with increasing length of an aliphatic pendant group R (CH3{, CH3(CH2)3{, CH3(CH2)5{, CH3(CH2)9{) has been performed. These polymers were synthesized using novel organometallic complex catalysts via an addition polymerization route. This reaction route maintained the bridged norbornene ring structure in the final polymer backbone. Gas...

Evidence from fMRI, ERPs, and intracranial recordings suggests the existence of face-specific mechanisms in the primate occipitotemporal cortex. The present study used a 64-channel MEG system to monitor neural activity while normal subjects viewed a sequence of grayscale photographs of a variety of unfamiliar faces and non-face stimuli. In fourteen out of fifteen subjects, face stimuli evoked a...

INTRODUCTION. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ......... 582 ALKALI-CATION SELECTIVITY IN NONLIVING SySTEMS..... . . . . . . . . . . . . . . .. 583 ALKALI-CATION SELECTIVITY IN BIOLOGICAL SYSTEMS. . . . . . . . . . . . . . . . . . .. 587 THE ORIGIN OF ALKALI-CATION EQUILIBRIUM SELECTIVITY .. .. . .. . .... . " 589 ANION SELECTIVITY. . . • . . . . . ....

low molecular weight organic acids are most predominant in apple juice among these components fumaric acid was not exceed more than 5 ppm. it was thought that the hplc is the best method of the determination of organic acids in the apple juice. in this study, chromatographic separation of organic acids of apple juice was obtained by preparing a sample and by applying them to acid phase for extr...

background: the abortifacient claim of senna alata (s. alata) was scientifically validated recently with alkaloids speculated to be the bioactive agent. this speculation is yet to be substantiated or refuted by scientific evidence. the present study was aimed to investigate the pregnancy terminating effects of the alkaloids from s. alata leaves. methods: twenty four pregnant rats (143.99±1.21 g...