A method to estimate the content of selenium in organics was introduced based on reversed phase-high performance liquid chromatography (RP-HPLC).The maximum absorption peak of piazselenol was at 330 nm and the optimized temperature and pH value were 40 degrees C and 2.8, respectively. The minimum detection concentration of selenium(IV) was 0.06 microg/mL and the measurable range was 0.12-12.0 m...

Two concepts are often currently applied to selenium in adult men in the United States: • Intake is generally enough to maximize blood glutathione peroxidase activities. • In such men, selenium supplementation does not reduce risk of prostate cancer. In contrast to these concepts, 30 healthy middle-aged men were studied to test the following hypothesis: 6-week supplementation of 200 μg of selen...

Selenium deficiency in rats for a period of up to 6 weeks inhibited both the production of 3,3',5-tri-iodothyronine (T3) from thyroxine (T4) (5'-deiodination) and also the catabolism of T3 to 3,3'-di-iodothyronine (5-deiodination) in liver homogenates. The hepatic stores of T3 were decreased by only 8% in selenium deficiency, despite the T3 production rate from T4 being only 7% of the rate foun...

BACKGROUND Evidence that selenium affects the risk of type-2 diabetes is conflicting, with observational studies and a few randomized trials showing both lower and higher risk linked to the level of selenium intake and status. We investigated the effect of selenium supplementation on the risk of type-2 diabetes in a population of relatively low selenium status as part of the UK PRECISE (PREvent...

BACKGROUND Selenium is an essential trace element found in cereals, wheat, dairy products, meat, and fish. This micronutrient may prevent carcinogenesis through several biochemical pathways; one suggested pathway is enhanced apoptosis. OBJECTIVES The relation between selenium and colorectal adenomas was evaluated because the colorectal adenoma is the established precursor lesion of most color...

The mechanism of selenium secretion by the mammary gland and effects of dietary copper and selenium metabolism on selenium in milk were investigated. Radioactive sodium selective selenite was injected into the jugular vein of lactating goats fed concentrates containing 15 or 115 ppm copper. Blood and milk samples were collected hourly for 8 h and daily for 1 wk. Whole blood, plasma, whole milk,...

Cancer prevention studies suggest that selenium is effective in reducing the incidence of cancers including prostate, colon, and lung cancers. Previous reports showed that selenium inhibits premalignant human breast MCF-10AT1 and MCF10AT3B cell growth in vitro and reduces mammary tumor incidence after exposure to carcinogens in tumor models. Because estrogen is critical to the development and d...

Selenium is essential to human health, and its deficiency is associated with different diseases including liver necrosis. Selenium is protective against viral hepatitis and hepatocellular carcinoma (HCC). The underlying molecular mechanisms of selenium effects are not well known. In this study, in vitro response of HCC-derived cell lines to selenium deficiency is examined alone or in conjunctio...

Selenium is a non-metallic chemical element of great important to human health. Low selenium levels in humans are associated with several pathological conditions and are a common finding in HIV infected individuals. We conducted a review of the literature to assess if selenium deficiency or selenium supplementation could play a role in modifying the clinical course of HIV disease. Several studi...

Selenium is known to be present in the bile of selenium-treated animais. Smith et al. (I) reported that rabbit bile, after acute and subacute poisoning with sodium selenite and selenate (0.5 to 3 mg. of selenium per kilo), contained smaller amounts of selenium (36 to 48 y per cent) after oral treatment than after intravenous treatment (336 y per cent). In studies by Dudley (2), it was found, af...