several plant extracts and phytoconstituents, despite having excellent bioactivity in vitro, demonstrate less or no in vivo actions due to their poor lipid solubility or improper molecular size or destruction in gut. drug delivery system for polyphenolic phytoconstituents (phytosomes) was prepared by complexing polyphenolic phytoconstituents with phospholipid mainly phosphatidylcholine which bi...

In this study, various formulations of solidified carvedilol-loaded SMEDDS with high loading (up to 67% w/w) were produced the spray drying process using porous silica-based carriers. The yield was improved higher atomization gas flow rate during and prolonged mixing time dispersion liquid solid carriers prior process. Depending on choice carrier SMEDDS:carrier ratio in SMEDDS, different drug l...

The number of options available to drug discovery scientists to enhance the solubility of poorly soluble compounds by conventional formulation approaches is limited. In most cases, drug formulation is oriented toward the creation of a supersaturated solution upon contact with aqueous environment, often combined with solubilizing agents and precipitation inhibitors. The most popular formulations...

in the long-term management of ulcerative colitis patients, repeat dosing maybe required. since 5-asa is largely absorbed from the upper intestine, selective delivery of drugs into the colon may be regarded as a better method of drug delivery with fewer side effects and a higher efficacy. the aim of this study was to prepare and evaluate a double coated multiparticulate system for 5-asa deliver...

BACKGROUND Self-emulsifying drug delivery system is an isotropic mixture of natural or synthetic oils, non-ionic surfactants or, one or more hydrophilic solvent and co-solvents/surfactant and polymer that improve bioavailability and increase solubility of poorly-soluble drugs. OBJECTIVES This study was aimed to prepare and develop a stable formulation for self-emulsifying drug delivery system...

Biphenyl Dimethyl Dicarboxylate (DDB) and Silymarin are widely used drugs for the treatment of hepatitis C virus, have poor bioavailability due to their low aqueous solubility that limits their dissolution rates. To overcome these limitations solid dispersions (SDs) and self-microemulsifing drug delivery systems (SMEDDS) were prepared in an attempt to improve their release profile. SDs were pre...

Objective: This study aimed to find the best SNEDDS meloxicam formula and analyze release kinetics of non-SNEDDS using DDSolver. 
 Methods: Meloxicam was prepared sunflower seed oil, Cremophor RH 40 as a surfactant, polyethylene glycol (PEG) 400 co-surfactant. Results: The obtained subjected in vitro dissolution analyzed shows one selected consists 10% 70% cremophor 40, 20% PEG with 20.5 n...