PURPOSE Limb remote ischemic per-conditioning or post-conditioning has been shown to be neuroprotective after cerebral ischemic stroke. However, the effect of combining remote per-conditioning with post-conditioning on ischemic/reperfusion injury as well as the underlying mechanisms are largely unexplored. METHODS Here, adult male Sprague Dawley rats were subjected to middle cerebral artery o...

For some time now, ‘semantic technologies’ are considered as the next big wave in Educational Technology and as the solution to many inherent problems. But the crop of actual systems and semantically enhanced learning objects is still meager. Semantic data extend ordinary data by explicitly marking up the objects involved and their relations among each other. This data-about-data aspect makes a...

Abstract In Evidence theory, several conditioning rules for updating belief have been proposed, including Dempster’s rule of conditioning. The paper views the conditioning rules proposed so far and proposes a new rule of conditioning based on three requirements. Then, it generalizes the rule to be applied to the case where condition is given by an uncertain belief. The paper also discusses a fe...

Eyeblink conditioning entails a variety of paradigms that differ in terms of the brain systems that support conditioning and the importance of awareness. In this issue, C. Bellebaum and I. Daum (2004) that reports that conditional discrimination learning depends on awareness. Their findings, along with other recent work, suggest a framework whereby the temporal features of the conditioning para...

Rorick-Kehn and Steinmetz (2005) report that neurons in the central and basolateral nuclei of the amygdala exhibit learning-related spike firing to conditional stimuli associated with shock in 3 different aversive conditioning paradigms: eyeblink conditioning, fear conditioning, and signaled avoidance conditioning. Central nucleus neurons responded in all 3 tasks, whereas basolateral nucleus ne...

To explore the role of spinal cord plasticity in motor learning, we evaluated the effects of H-reflex operant conditioning on GABAergic input to rat spinal motoneurons. Previous work indicated that down-conditioning of soleus H-reflex increases GABAergic input to soleus motoneurons. This study explored the effect of H-reflex up-conditioning on GABAergic input. Of nine rats exposed to H-reflex u...

The protective effects of cochlear pre-conditioning have been documented, especially in regard to noise. Conditioning with moderate-intensity noise toughens the ear and makes it more resistant to damage from high-level noise exposures. The goal of the project was to determine whether cochlear pre-conditioning is effective in protecting against the ototoxic effects of cisplatin. Pre-conditioning...

Four experiments studied anterograde deficits in Pavlovian fear conditioning following prolonged exposure to the mu-opioid receptor agonist morphine. Injections of morphine produced temporally graded anterograde amnesia characterized by deficits in contextual and conditioned-stimulus (CS) conditioning 1 or 7 days and selective impairment in CS conditioning 21 days after last injection. This ant...