abstract the objective of present study was to evaluate pharmacokinetic parameters of dibudipine phytosolve after oral administration in rats. the solubility test was carried out to select suitable oily solvent for dibudipine. phytosolve formulation was prepared with a medium chain triglyceride (mct) oil (20%), soybean phospholipids (5%) and a 70% fructose solution (75%). the effect of polyol c...

omega-3 fatty acids (fas) have been shown to prevent cardiovascular disease. the most commonly used omega-3 fatty acids like eicosapentaenoic acid (epa) and docosahexaenoic acid (dha) are highly vulnerable to oxidation and therefore, have short shelf life. recent advances in nanoliposomes provided a biocompatible system for stabilizing omega-3 fas. several methods could be implemented to prepar...

in order to improve local therapeutic techniques for the massively burnt patients and to minimize the pain associated with dressing change, the concept of topical film was utilized to formulate a topical antimicrobial spray. the commonly used topical antimicrobial silver sulfadiazine spray was formulated as a new drug delivery system. the release of therapeutic agents in vitro from medicated sp...

There are many causes of disturbed bowel habits. In this rare case of mucocele of appendix, patient presented with disturbed bowel habits of increased frequency, urgency and semisolid stool. Ultrasound of abdomen revealed fusiform cyst just below umbilicus. Differential diagnoses included mesenteric cyst, duplication cyst and mucocele of appendix. Coronal and saggital reformats of CT abdomen co...

The swarming phenomenon of 18 strains was tested with the intention to identify motile, swarming bacteria. Not all bacteria which are motile in liquid are able to swarm on semisolid nutrient broth, but all swarming bacteria show characteristic swarming developments, resulting in different swarming zones which could be scanned densitometrically. The densitograms are fully reproducible for the sa...

We compared the eSwab system to a swab with an anaerobic transport semisolid agar system for their capacities to maintain the viability of 20 species of fastidious anaerobes inoculated on the bench and held at ambient or refrigerator temperature for 24 or 48 h. On average, both systems maintained similar viabilities among analogous groups of organisms at both temperatures, although there were q...

Partially purified staphylococcal hyaluronidase was studied with respect to its electrophoretic properties by the use of starch slurry or semisolid Noble agar as a matrix. The polarity of enzyme activity was found to be cathodal on starch and anodal on agar gel. The electrophoretic migration of the partially purified enzyme on starch, as a function of pH, suggested that the enzyme has an isoele...