The present work offers an analysis of the historical development of the discovery and use of barbiturates in the field of psychiatry and neurology, a century after their clinical introduction. Beginning with the synthesis of malonylurea by von Baeyer in 1864, and up to the decline of barbiturate therapy in the 1960s, it describes the discovery of the sedative properties of barbital, by von Mer...

Methagoalone, a relatively new sedative hypnotic dmg in the United States, has unique prop& which make the handling of overdosage somewhat different from the stnndard procedures. We report the case of a 20-y&d woman who ingested a large quantity of the drug and required ambat ion and artificial ventilation during the c o w of her recovery. The paper recounts the &tells of thb treatxwnt and revi...

Most sedative-hypnotics used in insomnia treatment target the gamma-aminobutyric acid (GABA)(A) receptors. A vast repertoire of GABA(A) receptor subtypes has been identified and displays specific electrophysiological and functional properties. GABA(A)-mediated inhibition traditionally refers to 'phasic' inhibition, arising from synaptic GABA(A) receptors which transiently inhibit neurons. Howev...

Background:Endoscopic retrograde cholangiopancreatography (ERCP), often require sedation during the procedure. The most commonly used drugs for this purpose are midazolam and propofol, which as sedative hypnotic agents with minimal analgesic potential. Aims & objectives:Effects of Sedoanalgesia Midazolam/ ketamine long Dexmedetomidine nfusion Rescue propofol alliquotes regimes on hemodynami...

BACKGROUND Use of psychotropic and sedative drugs has been associated with impaired muscle strength. Muscle weakness predicts important outcomes for older people including functional disability and mortality. The objective of this study was to investigate if the use of drugs with sedative properties is associated with poorer muscle strength. METHODS Seven-hundred community-dwelling participan...