The brain in sepsis Intensive care clinicians will be familiar with the acute brain syndrome observed in patients with sepsis, variously described as “septic encephalopathy” or “sepsis-associated brain dysfunction”.1 Less well appreciated are the long-term morbidity and mortality associated with this condition. Enduring, newonset, moderate-to-severe cognitive impairment is seen in at least 10% ...

Sepsis is a severe and complex syndrome that lacks effective prevention or therapeutics. The effects of sepsis on the microvasculature have become an attractive area for possible new targets and therapeutics. Microparticles (MPs) are cell membrane-derived particles that can promote coagulation, inflammation, and angiogenesis, and they can participate in cell-to-cell communication. MPs retain ce...

Objective: To determine the clinical significance sof Delta Neutrophil Index (DNI) in diagnosing sepsis.
 Study Design: Cross-sectional study.
 Place and Duration of Study: Department Pathology, Pakistan Navy Ship, Shifa Hospital, Karachi from Jan to Jun 2020.
 Methodology: The study included one hundred fifty patients with systemic inflammatory response syndrome (SIRS) sadmitted...

This study retrospectively investigated the significance of whole body CT (WCT) for patients with sepsis. A medical chart review was retrospectively performed for all patients with systemic inflammatory response syndrome that were treated initially between April 2011 and March 2012. The subjects were divided into a WCT group that underwent WCT on arrival and a control group. Results of this stu...

Infectious disease is common in stem cell transplant recipients, especially in the patients of primary immunodeficiency disease (PID). However, there’s little report about sepsis and meningitis caused by enterococcus faecium (EF). Meningitis and sepsis caused by EF is uncommon in stem cell transplant recipients. We report a case of EF meningitis and sepsis which occurred in a 2-year-old boy wit...

OBJECTIVES To compare serum concentrations of homocysteine in healthy dogs and those fitting the criteria for systemic inflammatory response syndrome and to compare these values to commonly measured B-vitamins. METHODS Study dogs were classified into non-infectious systemic inflammatory response syndrome or sepsis groups and blood was drawn on Day 1 of the patient's hospitalisation for measur...

Despite considerable progress, peritonitis and sepsis remain life-threatening conditions. To improve the understanding of the pathophysiology encountered in sepsis, a new standardized and highly reproducible murine model of abdominal sepsis termed colon ascendens stent peritonitis (CASP) was developed. In CASP, a stent is inserted into the ascending colon, which generates a septic focus. CASP e...

Despite advances in intensive care and the widespread use of standardized care included in the Surviving Sepsis Campaign Guidelines, sepsis remains a leading cause of death, and the prevalence of sepsis increases concurrent with the aging process. The diagnosis of sepsis was originally based on the evidence of persistent bacteremia (septicemia) but was modified in 1992 to incorporate systemic i...

Sepsis is an infection-induced inflammatory syndrome that results in a complex network of adaptive and maladaptive alterations in homeostatic mechanisms. Severe sepsis, defined as sepsis associated with acute organ failure, is a serious disease with a mortality rate of 30-50%. The coagulation system, through complex interactions, has an important role in the final outcome of the sepsis-induced ...

INTRODUCTION Sepsis is a syndromic illness that has traditionally been defined by a set of broad, highly sensitive clinical parameters. As a result, numerous distinct pathophysiologic states may meet diagnostic criteria for sepsis, leading to syndrome heterogeneity. The existence of biologically distinct sepsis subtypes may in part explain the lack of actionable evidence from clinical trials of...