Kanabidiol, CB1 ve CB2 reseptörlerine düşük bağlanma eğilimine (afiniteye) sahip psikoaktif özellikleri olmayan bir kanabinoiddir. Ayrıca G proteinine bağlı reseptörler, serotonin reseptörleri opioid ile de aktivite göstermektedir. Bu nedenle kanabidiol uzun zamandır anksiyete, depresyon, refrakter epilepsi gibi nöronal hastalıkların, Parkinson, Alzheimer hastalığı, amyotrofik lateral skleroz s...

Prefrontal-subcortical circuits support executive functions which often become dysfunctional in psychiatric disorders. Vortioxetine is a multimodal antidepressant that is currently used in the clinic to treat major depressive disorder. Mechanisms of action of vortioxetine include serotonin (5-HT) transporter blockade, 5-HT1A receptor agonism, 5-HT1B receptor partial agonism, and 5-HT1D, 5-HT3, ...

Decreased serotonergic activity has been implicated in anxiety and major depression, and antidepressants directly or indirectly increase the long-term activity of the serotonin system. A key component of serotonin circuitry is the 5-HT1A autoreceptor, which functions as the major somatodendritic autoreceptor to negatively regulate the "gain" of the serotonin system. In addition, 5-HT1A heterore...

Serotonin (5-hydroxytryptamine) is an endogenous compound located mainly in the enterochromaffin cells of the gastrointestinal tract, serotonergic neurons, and platelets. Physiologically 5-HT acts as a neurotransmitter, neuromodulator and vasoconstrictor [1]. Imaging studies related to the processes of synthesis and serotonin sequestering/release from secretory vesicles are essential for the un...

The known Gly56Ala mutation in the serotonin transporter SERT (or 5-HTT), encoded by the SLC6A4 gene, causes increased serotonin reuptake and has been associated with autism and rigid-compulsive behavior. We report a patient with macrocephaly from birth, followed by hypotonia, developmental delay, ataxia and a diagnosis of atypical autism (PDD-NOS) in retrospect at the age of 4½years. Low level...

In 1957 we demonstrated a defect of 5-hydroxyindole metabolism in 10 patients with phenylketonuria and suggested that, in view of the probable importance of 5-hydroxytryptamine (5HT) in normal brain function, this deficiency might be a factor in the mental defect (Pare, Sandler and Stacey, 1957). In the work described below, the previous findings are extended and the relationship of the 5-hydro...

An enzymatic preparation from human brain converts tryptamine to tryptoline (9H-1,2,3,4-tetrahydropyrido(3,4-b)indole) in the presence of 5-methyltetrahydrofolic acid. Similarly, N-methyltryptamine and 5-hydroxytryptamine yield 1-methyltryptoline and 5-hydroxytryptoline, respectively. Neither in vitro nor in vivo formation of these compounds by human tissues has been described.

d-lysergic diethylamide (LSD) is a hallucinogenic drug that interacts with the serotonin (5-HT) system binding to 5-HT1 and 5-HT2 receptors. Little is known about its potential interactions with the dopamine (DA) neurons of the ventral tegmental area (VTA). Using in-vivo electrophysiology in male adult rats, we evaluated the effects of cumulative doses of LSD on VTA DA neuronal activity, compar...

The modulation of acetylcholine (ACh) release by 5-HT3 receptor activation was studied using in vivo microdialysis. Spontaneous and K+-stimulated ACh release were measured in frontoparietal cortex and hippocampus of freely moving rats. Two consecutive exposures to high K+ produced ACh release of similar magnitude. In the cortex, serotonin (5-HT) failed to alter spontaneous ACh release, but caus...