UNLABELLED Serum amyloid P component (SAP) binds to amyloid. (123)I-SAP scintigraphy is used to evaluate the extent and distribution of amyloid in systemic amyloidosis and has great clinical value in the detection of systemic amyloidosis. The aim of the study was to assess during scintigraphy the diagnostic performance and prognostic value of a simple parameter describing extravascular (123)I-S...

BACKGROUND AA amyloidosis develops in patients with chronic inflammatory diseases. The AA amyloid proteins are proteolytic fragments obtained from serum amyloid A (SAA). Previous studies have provided evidence that endosomes or lysosomes might be involved in the processing of SAA, and contribute to the pathology of AA amyloidosis. OBJECTIVE To investigate the anatomical distribution of cathep...

Psoriatic spondyloarthropathy (PSA) can occasionally be complicated by AA amyloid, and renal amyloidosis should be suspected in patients with PSA who have unexplained proteinuria. The diagnosis of amyloidosis can be made either histologically or by radiolabelled serum amyloid P component (SAP) scintigraphy. Prognosis is determined by the extent of organ involvement and associated impairment of ...

Amyloidosis is a disorder of protein conformation and metabolism that results in the depo‐ sition of insoluble amyloid fibrils in tissues, which causes organ dysfunction; systemic amy‐ loidosis is characterized by failure of multiple organs and the presence of amyloid precursor protein in the serum [1-3]. Reactive amyloid A (AA) amyloidosis is one of the most severe complications of several chr...

A 13-year-old girl was diagnosed with non-cystic fibrosis (CF)-related multifocal bronchiectasis accompanied by nephrotic-range proteinuria of unknown cause. On renal biopsy, there were many segmental homogeneous deposits of amyloid tissue with positive Congo red staining in the glomeruli and interstitium. On electron microscopy, relatively straight, non-branching, randomly arranged amyloid fib...

Type 1 diabetes (T1D) is expected to cause significant changes in the serum proteome; however, few studies have systematically assessed the proteomic profile change associated with the disease. In this study, a semiquantitative spectral counting-based two dimensional liquid chromatography mass spectrometry platform was used to analyze serum samples from T1D patients and controls. In this discov...

Objective: To investigate The level of serum amyloid A protein (SAA) in systemic lupus erythematosus (SLE) patients and its importance in disease activity. Materials and Methods: Fortytwo female patients who satisfied four or more of the revised ACR criteria for SLE were included in this study. Fifteen healthy female subjects matched for age were included as controls. Disease activity was asses...

Amyloidosis constitutes a spectrum of diseases, unified by the morphological appearance of the amyloid protein deposits, the cardinal feature of this disorder. The term “amyloid” was first coined in 1838 to describe plant starch and was adopted by Rudolph Virchow in 1854 to describe amyloid deposits in tissues, because of its similarity to cellulose stained with iodine. Amyloidosis results from...

It is a striking observation that tissue of patients invaded by the deep mycoses often lacks evidence of an inflammatory response. This lack of host response is often attributed to neutropenia secondary to chemotherapy. However, systematic studies do not support this simplistic explanation. However, invasive fungal lesions are characterized by abundant fungal functional amyloid, which in turn i...