Specific antimicrobial antibodies present in the sera of patients with inflammatory bowel disease (IBD) have been proven to be valuable serological biomarkers for diagnosis/prognosis of the disease. Herein we describe the use of a whole Escherichia coli proteome microarray as a novel high throughput proteomics approach to screen and identify new serological biomarkers for IBD. Each protein arra...

OBJECTIVE Chronic hepatitis C virus (HCV) has been linked to extrahepatic autoimmune phenomena. In addition, a variety of autoantibodies are found in patients with HCV. The prevalence, nature, and clinical significance of anticardiolipin (aCL) autoantibodies in serum samples of patients with HCV were therefore investigated. PATIENTS AND METHODS A prospective study of 48 consecutive patients w...

Exposure to heavy metals may have toxic effects on several human organs causing morbidity and mortality. Metals trigger or exacerbate autoimmunity in humans. Inbred mouse strains with certain H-2 haplotypes are susceptible xenobiotic-induced autoimmunity; their immune response such as mercury, gold, silver been explored. Serum antinuclear antibodies (ANA), polyclonal B-cell activation, hypergam...

Monoclonal antibodies were generated from mice immunized with scolex protein antigen of Cysticercus cellulosae. Three monoclonal antibodies specific for cysticercal antigens, which did not show any cross-reactivity with Taenia solium or Taenia saginata antigens, were selected. Each monoclonal antibody coupled to Sepharose could purify one antigen, which appeared as a single band on polyacrylami...

OBJECTIVES Previous studies of small numbers of patients have shown that antisulphatide autoantibodies are associated with polyneuropathies having a prominent sensory component. However, clinical and electrodiagnostic features are variable. The range of clinical and electrodiagnostic findings in 19 patients with polyneuropathies and high titre (> 4500) serum IgM antisulphatide antibodies is des...

Viruses are a common cause of eye infection. The local mucosal response, with production of antibodies released into tears, is believed to provide an important immune defense against these agents. However very little information exists on the viral specificity of normal tear immunoglobulins. In this study we obtained tears, parotid saliva and serum from 40 normal subjects without eye disease. S...

Hepatitis is a disorder in liver inflammation that can be caused by infection with parasites, protozoa, bacteria, viruses, metabolic disorders, drugs, and alcohol causes damage to human cells attack all ages, genders, races throughout the world. Serum Glutamic Oxaloacetic Transaminase (SGOT) Pyruvic (SGPT) levels EDTA plasma tend increase more than serum. It because contains coagulation factors...

The aim of the work was to study clinical and immunological relevance quantification antibodies type I, II, III collagen elastin in systemic scleroderma. 51 scleroderma patients with verified diagnosis different disease activity were included study. 30 healthy volunteers control group. laboratory markers assessed both on admission discharge. Antibodies serum or collagen, measured using ELISA te...

bronchiectasis is a chronic debilitating condition characterized by abnormal dilated thick-walled bronchi. to investigate humoral immune function in bronchiectatic patients, this study was performed . forty patients with established diagnosis of bronchiectasis, who were referred from two tertiary care pulmonology centers in tehran, were investigated in this study. immunoglobulin isotypes concen...