In this study we investigated if peroxisome proliferator-activated receptor β/δ activation protects from copper-induced acute liver damage. Mice treated with copper had significant body weight loss, serum alanine aminotransferase increase, modest changes in liver histology, increase of tumor necrosis factor α and macrophage inflammatory protein 2 mRNA and 8-hydroxy-2'-deoxyguanosine. Mice treat...

Copper is an essential micronutrient for human bodies, whose distribution in different organs and tissues, metabolism and physiological impact is not thoroughly explained yet. Further issues which need clarification are the exact composition and constitution of its combinations with other elements, the physiological impact of copper and copper-enzymes in sickness and health. Biomarkers for iden...

BACKGROUND AND AIM Trace elements and vitamins play a vital role in human body to perform its function properly. Thalassemic patients are at risk of micronutrient deficiency. This study estimated levels of vitamins A, C, E, B12, folic acid, total homocysteine (tHcy), and methylmalonic acid (MMA) along with trace elements, zinc, copper, and selenium in Beta-thalassemia-major patients. METHODS ...

PURPOSE Tetrathiomolybdate (TM), a copper-lowering agent, has been shown in preclinical murine tumor models to be antiangiogenic. We evaluated the antitumor activity of TM in patients with advanced kidney cancer in a Phase II trial. EXPERIMENTAL DESIGN Fifteen patients with advanced kidney cancer were eligible to participate in this trial. TM was initiated p.o. at 40 mg three times a day with...

Background. Alopecia areata (AA) is an autoimmune condition, in which hair is lost from some areas of the body. Though its etiopathogenesis is not fully understood, there are claims that imbalance of trace elements may trigger the onset of AA, by distorting immune functions. In this study, we tried to investigate the relationship between AA and iron, zinc, and copper levels of serum and hair. M...

The present study was conducted with the objective to the iron, copper and zinc variations in serum of Nili-Ravi buffaloes during pre and post partum periods determine. The study was carried out on 35 pregnant Nili-Ravi buffaloes during June 2008 to October 2008 at Buffalo Research Institute, Pattoki, District Kasur. Blood samples were taken from these buffaloes during three, two and one week b...

Neurological signs like ataxia and hind limb paresis have often been reported in cheetahs (Acinonyx jubatus), lions (Panthera leo) and snow leopards (Panthera unica). As a cause, copper and Vitamin A deficiencies have been discussed. Many cases were seen in cheetahs and lions in the United Arab Emirates (UAE) within the last years. The aim of this study was to find correlations between nutritio...

Male BALB/c mice were infected with a single cercarial dose of Schistosoma mansoni and later treated curatively with praziquantel on Day 42 post-infection. Serum from the animals was studied for changes in concentration of haptoglobin, albumin, iron, zinc and copper. The infection resulted in significant decreases in serum albumin, iron and zinc, and increases in serum haptoglobin and copper. H...

this experiment was conducted to investigate the effects of various levels of cichorium intybus andcopper on performance and egg yolk cholesterol. total of 324 layer hens (hy-line w-36) were used in arandomized complete blocks with nine treatments, three replications of 12 birds in each from 38 to 50weeks of age. experimental diets include control, four levels of copper (150, 200, 250 and 300 m...