An elderly lady was diagnosed with primary hyperparathyroidism after being admitted to hospital with pyelonephritis and constipation. A sestamibi parathyroid scan demonstrated increased uptake in the upper mediastinum, suggesting an ectopic mediastinal parathyroid adenoma. The 4-mm adenoma was successfully removed through a mini-sternotomy incision using a gamma probe to identify the gland from...

Scintimammography performed with Tc-99m sestamibi in a 63-year-old woman with a history of mitral valve replacement and pulmonary hypertension demonstrated that the frequently observed sternal hyperactivity on anterior views could arise from the myocardium. Caution therefore should be taken before the diagnosing hyperactivity in the lower sternal region as a neoplastic involvement. Fig. 1. Scin...

INTRODUCTION Reperfusion therapy with either thrombolysis or angioplasty has been shown to be beneficial in acute myocardial infarction. Tc-99m sestamibi is a myocardial tracer that can be used to assess myocardial salvage because of its property of very limited redistribution. MATERIALS AND METHODS To assess the feasibility of this technique locally, Tc-99m sestamibi was injected before and ...

HYPOTHESIS Results of reoperative parathyroid surgery (RPS) have improved with the advent of sestamibi parathyroid subtraction scanning and intraoperative parathyroid hormone (IOPTH) monitoring. DESIGN Retrospective review of patient histories, preoperative localization studies, operative data, including IOPTH monitoring, and outcomes for patients undergoing recent RPS at a single institution...

BACKGROUND Exercise gated single-photon emission computed tomography (SPECT) using technetium-99m (99mTc)-sestamibi evaluates both myocardial perfusion during stress and wall motion >30 min after the stress, which has the potential to assess not only exercise-induced myocardial ischemia but also the development of myocardial stunning. METHODS AND RESULTS To evaluate the incidence of post-stre...

PURPOSE To test whether epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI) induce detectable signals in tumor cells and whether such signals may reveal alterations of the apoptotic program. EXPERIMENTAL DESIGN Tumor cells were treated with gefitinib or erlotinib and tested for their ability to accumulate 99mTc-Sestamibi, a radiolabeled lipophilic cation that localizes in...

INTRODUCTION Dobutamine stress echocardiography (DSE) and myocardial perfusion scan (MPS) are commonly used to detect viable myocardium. We designed this study to compare the results of these two methods in detecting myocardial viability. METHODS We studied 736 segments from 46 patients (42 men, mean age 56 years), with coronary artery disease and impaired left ventricular systolic function (...

OBJECTIVE 99mTc-tetrofosmin and 99mTc-sestamibi are approved tracers for myocardial perfusion studies. Recently, a 99mTc-MIBI preparation from a different manufacturer (99mTc-cardiospect-MIBI) has been introduced to the market. Therefore, the aim of this study was the evaluation of 99mTc-tetrofosmin as well as of two different 99mTc-labeled MIBI tracers with regard to differences in imaging qua...

mammography remians the procedure of choice in screening asymptomatic women for breast cancer. however, in patients with symptoms, other types of imaging play an important role in the detection of malignancies. the high cost and lack of availability of pet and mri largely precludes the use in this patient population. ti-201 is nbt the imaging agent of choice because of its wash-out and redistri...

BACKGROUND Low-dose dobutamine stress echocardiography is increasingly used for identifying myocardial viability. AIM We explored whether dobutamine-induced strain (S) and strain rate (SR) can identify myocardial viability following fibrinolytic therapy for ST-segment-elevation myocardial infarction (STEMI), taking (99m)Tc-sestamibi scintigraphy as the "gold standard" for diagnosis. METHODS...