OF THESIS Structural Analysis of the Drosophila Innexin ShakB: Role of the N-Terminus in Rectifying Electrical Synapses Gap junction channels mediate direct intercellular communication in all multicellular animals. They are comprised of the connexin family of proteins in vertebrates and the innexin family in prechordates. Connexins and innexins share many functional and structural similarities ...

The biologically active compounds raphasatin and sulforaphene are formed during the hydrolysis of radishes by an endogenous myrosinase. Raphasatin is very unstable, and it is generated and simultaneously degraded to less active compounds during hydrolysis in aqueous media. This study determined the hydrolysis conditions to maximize the formation of raphasatin and sulforaphene by an endogenous m...

Fluid shear stress (FSS) induces a series of biochemical responses in osteoblasts, and this "mechanoresponse" regulates their survival, proliferation and differentiation. However, the events in cells immediately after FSS application are unclear, and how biochemical signals from soluble factors modify the mechanoresponses is largely unknown. We used the orbital shaking method, instead of the fr...

[1] The October 1999 Mw 7.1 Hector Mine earthquake in the Mojave Desert, California, generated characteristic surface disturbances on nearby desert pavements. These disturbances included (1) zones of wholesale gravel displacement interspersed with zones of intact pavement, (2) displaced and rotated cobbles, (3) moats around loosened, embedded boulders, (4) filling of abandoned cobble sockets, b...

introduction: the basic objective of this study is to investigate the effects of alpha and theta brain waves amplitude increase in occipital area on reducing the severity of symptoms of generalized anxiety disorder and to increase the global functioning level in patients with gad. methods: this study is a quasi-experimental study with pre-test and post-test with two groups. for this purpose, 28...

Shaken baby syndrome is a term often used by physicians and the public to describe abusive head trauma inflicted on infants and young children. Although the term is well known and has been used for a number of decades, advances in the understanding of the mechanisms and clinical spectrum of injury associated with abusive head trauma compel us to modify our terminology to keep pace with our unde...

Here we demonstrate a model that combines Tweets following significant earthquakes with basic site and earthquake characteristics to produce a rapid estimate of the ground shaking intensity. We used all geo-tagged Tweets around the world containing the keyword “earthquake” or “tsunami” in several languages that occurred in the first 10 minutes following Japanese earthquakes of magnitude 6 or gr...

The lysosomal enzyme glucocerebrosidase, encoded by the glucocerebrosidase gene, is involved in the breakdown of glucocerebroside into glucose and ceramide. Lysosomal build-up of the substrate glucocerebroside occurs in cells of the reticulo-endothelial system in patients with Gaucher disease, a rare lysosomal storage disorder caused by the recessively inherited deficiency of glucocerebrosidase...

ence in the productivity of the vegetation on the control plots. Odum et al. (2) observed comparable differences in productivity during old field succession, but these were attributable to previous fertilization and changes in the growth forms of the dominants, factors not adequately discussed by Hurd et al. We have also observed significant differences in the primary production of herbaceous c...