OBJECTIVE Low wall shear stress has been implicated in atherogenesis throughout the arterial tree, including the right coronary artery (RCA). The objective of this study was to determine the level of covariation of intimal thickness and wall shear stress in the human RCA. METHODS AND RESULTS Postmortem histological measurements of intimal thickness were compared with wall shear stresses calcu...

the effects of physical, thermal and mechanical parameters on curing microthermal residual stresses are studied, based on the energy method, to present a theoretical solution for prediction of residual stress felds. a fnite element analysis is developed to compare the theoretical and numerical results together. there is found to be a good agreement between the results of the two methods. howeve...

The effects of an overlapping stenosis on blood flow characteristics in a narrow artery have been investigated. To account for the non-Newtonian behavior, blood has been represented by a Casson fluid. The equation describing the flow has been solved and the expressions for the flow characteristics, namely, the impedance, the wall shear stress, the shear stress at the stenosis throats and the sh...

The rheology of suspensions showing discontinuous shear thickening (DST) is well documented in conventional rheometer with rotating tools, but their study capillary flow still lacking. We present results obtained a homemade working an imposed pressure regime. show that the shape experimental curve giving volume rate versus wall stress can be qualitatively reproduced from rotational geometry at ...

Shear stress stimulus is expected to enhance angiogenesis, the formation of microvessels. We determined the effect of shear stress stimulus on three-dimensional microvessel formation in vitro. Bovine pulmonary microvascular endothelial cells were seeded onto collagen gels with basic fibroblast growth factor to make a microvessel formation model. We observed this model in detail using phase-cont...

Alterations in the functions of vascular endothelial cells (ECs) induced by fluid shear stress may play a pivotal role in both the development and prevention of vascular diseases. We found that DNA synthesis of bovine aortic and human umbilical vein ECs, determined by [(3)H]thymidine incorporation, was inhibited by steady laminar shear stress (5 and 30 dyne/cm(2)). This growth inhibition due to...

The interaction between the vascular endothelium and hemodynamic forces (and more specifically, fluid shear stress), induced by the flow of blood, plays a major role in vascular remodeling and in new blood vessels formation via a process termed arteriogenesis. Tie1 is an orphan tyrosine kinase receptor expressed almost exclusively in endothelial cells and is required for normal vascular develop...

Alterations in the functions of vascular endothelial cells (ECs) induced by fluid shear stress may play a pivotal role in both the development and prevention of vascular diseases. We found that DNA synthesis of bovine aortic and human umbilical vein ECs, determined by [H]thymidine incorporation, was inhibited by steady laminar shear stress (5 and 30 dyne/cm). This growth inhibition due to shear...