Cerebral amyloid-beta (Abeta) deposition is central to the neuropathological definition of Alzheimer disease (AD) with Abeta related toxicity being linked to its beta-sheet conformation and/or aggregation. We show that a beta-sheet breaker peptide (iAbeta5) dose-dependently and reproducibly induced in vivo disassembly of fibrillar amyloid deposits, with control peptides having no effect. The iA...

During the last decades, society’s concern for the environment has increased. Specific tools like the Life Cycle Assessment (LCA), and software and databases to apply this method have been developed to calculate the environmental burden of products or processes. Calculating the environmental impact of plastic products is relevant as the global plastics production rose to 288 million tons in 201...

Process analysis and simulations on molding experiments of 3D thin shell parts have been conducted. Moldings were carried out with polyoxymethylene (POM). The moldings were performed with cavity pressure sensors in order to compare experimental process results with simulations. The warpage was characterized by measuring distances using a tactile coordinate measuring machine (CMM). Molding simul...

BACKGROUND Gingivoperiosteoplasty can avoid secondary alveolar bone grafting in up to 60 percent of patients with a cleft. However, preoperative predictors of success have not been characterized. This study reports on the preoperative alveolar segment position most favorable for successful gingivoperiosteoplasty. METHODS The authors performed a single-institution, retrospective review of pati...

The objective of this study was to manufacture new biodegradable fiberboards by thermo-pressing. The starting material was deoiled cake (only 0.9% oil content), generated during the biorefinery of sunflower (Helianthus annuus L.) whole plant in a co-rotating twin-screw extruder. All fiberboards were cohesive mixtures of proteins and lignocellulosic fibers, acting respectively as binder and rein...

Waste molding sands from the foundry industry have been successfully used as a component in manufactured soils, but concern over metal contamination must be addressed before many states will consider this beneficial use. Since there is little data available on this topic, the purpose of this study was to characterize total and leachable metals from waste molding sands. A total elemental analysi...

Compression molding process can potentially be used to make high precision glass lenses. In a lens molding process, glass raw material is heated above its transition temperature and is subsequently pressed between the two mold halves into a lens shape. Controlled cooling (annealing) of the formed lens is then carried out with the molds in a closed position in order to enable uniform cooling of ...

This paper proposes a neuro-fuzzy approach for optimizing injection molding parameter settings. The approach consists of design of experiments and neuro-fuzzy systems. Experimental data shows that the proposed approach performs better than the traditional trial and error practices usually involved in the injection molding process.

Objectives The authors performed a systematic review to evaluate the potential beneficial effects of the nasoalveolar molding appliance on nonsyndromic unilateral clefts of the lip and/or palate prior to primary lip repair. Material and Methods A literature search was performed using three electronic databases (PubMed, Embase, Web of Science) and three journals ("Cleft Palate-Craniofacial Jou...