Peroxisome inheritance at the right time and place E very yeast cell has numerous peroxi-somes—organelles that metabolize fatty acids— and roughly half are passed on to their daughter cells. Signaling from the bud to the mother cell ensures even peroxisome distribution by controlling the organelles' transport, say Fagarasanu et al. Peroxisomes travel into the bud along actin tracks using the my...

METHODS of shortening a curve in a manifold have been used to establish the existence of closed geodesics, and in particular of simple closed geodesics on 2-spheres. For this purpose, a curve evolution process should (a) not increase the number of self-intersections of a curve, (b) exist for all time or until a curve collapses to a point, (c) shorten curves sufficiently fast so that curves whic...

Postsystolic shortening and thickening of ischemic and postischemic myocardium are wellrecognized phenomena, but their significance is controversial. To discover whether postsystolic shortening and thickening might represent an active process and to establish their place as possible predictors of functional recovery during and after recovery from ischemia, we examined correlations in severely i...

Telomeres are progressively eroded during repeated rounds of cell division due to the end replication problem but also undergo additional more substantial stochastic shortening events. In most cases, shortened telomeres induce a cell-cycle arrest or trigger apoptosis, although for those cells that bypass such signals during tumour progression, a critical length threshold is reached at which tel...

Background: Chronic Obstructive Pulmonary Disease (COPD) may be associated with accelerated aging. Telomere shortening is a biomarker of aging. Cross-sectional studies describe shorter telomeres in COPD compared with matched controls. No studies have described telomere length trajectory and its relationship with COPD progression. We investigated telomere shortening over time and its relationshi...

Cell senescence, originally defined as the proliferative arrest that occurs in normal cells after a limited number of cell divisions, is now more broadly regarded as a general biological program of terminal growth arrest. Replicative senescence of cells due to telomeric changes exhibits similar features with those seen in DNA damage (Vaziri et al., 1997; von Zglinicki, 2001). Therefore, DNA dam...