Stem cell transplantation may lead to prolonged disease-free survival in young patients with high-risk myelodysplastic syndrome (MDS) and secondary acute myeloid leukemia. About one-third of patients transplanted with an HLA-identical family donor will experience long-term disease-free survival. Outcome appears to be better for younger patients, patients with less advanced stages of MDS and tre...

Children who would benefit from a haematopoietic stem cell transplantation often lacked a compatible sibling donor. Unrelated cord blood transplantation was offered as an alternative donor source for patients with a variety of malignant and non-malignant diseases who had no further treatment options. Cord blood units were sourced from various international cord blood registries. The median nucl...

Severe aplastic anemia (SAA) patients without an HLA-matched sibling donor need alternative treatment options. Umbilical cord blood transplantation (UCBT) has become an alternative means for treating various diseases, but it has not been proved to be a satisfactory method to treat SAA. Here, we report the case of a girl who underwent successful two-unit UCBT after engraftment failure with a sin...

Myelodysplastic syndromes are clonal disorders with morphological dysplasia, a variable degree of cytopenia and risk transformation to acute myeloid leukemia. Prognosis is very defined by blast count, cytopenia, cytogenetics more recently somatic mutations, IPSS or revised score being the most widely used assess disease risk. HSCT remains only curative treatment date, high-risk patients obtaini...

Hereditary mutations associated with hematologic malignancies are rare. Heterozygous mutations affecting the hematopoietic transcription factor CBFA2 (also AML1/RUNX1) were recently reported to be associated with familial platelet disorder with predisposition to acute myeloid leukemia (FPD/AML, MIM 601399). A new 3-generation family with FPD/AML with a novel CBFA2 mutation is described. In this...

A 35-year-old male with a FLT3(+) AML underwent allogeneic peripheral blood stem cell transplant using a myeloablative non-total body irradiation (TBI) conditioning regimen from his HLA-matched sibling donor. Following transplantation, he developed grade II acute graft-versus-host disease (GVHD) that resolved with increasing immunosuppression. The medications were subsequently discontinued, and...

The current investigation examined the long-term prediction of sibling jealousy assessed in a laboratory-based paradigm on sibling relationship quality 2 1/2 years later. This multi-method longitudinal study included mothers, fathers, and two children from 35 families. Younger siblings were 16 months and older siblings were, on average, 4 years at Time 1. Positive longitudinal associations were...