In this chapter, the authors establish the existence of a synergistic relationship between two complementary methodologies, Business Process Management (BPM) and Six Sigma, through literature review and suggest methods to exploit the same. Six Sigma provides incremental improvement through its analytical abilities and is complemented by BPM which provides the data from the ongoing processes on ...

This paper describes an analog-to-digital converter which combines multiple delta-sigma modulators in parallel so that time oversampling may be reduced or even eliminated. By doubling the number of L th-order delta-sigma modulators, the resolution of this architecture is increased by approximately L bits. Thus, the resolution obtained by combining M delta-sigma modulators in parallel with no ov...

Sigma receptors are unique endoplasmic reticulum proteins that mediate signaling for a variety of drugs. We determined the effect of sigma(1) receptor agonists on immune responses in a syngeneic lung cancer model. Sigma(1) receptor agonists, including cocaine, up-regulated splenocyte IL-10 mRNA and protein production in vitro in a sigma receptor-dependent, pertussis toxin-sensitive manner. In v...

This paper describes an analog-to-digital converter which combines multiple delta–sigma modulators in parallel so that time oversampling may be reduced or even eliminated. By doubling the number of Lth-order delta–sigma modulators, the resolution of this architecture is increased by approximately L bits. Thus, the resolution obtained by combining M delta–sigma modulators in parallel with no ove...

The sigma-1 receptor is widely distributed in the central nervous system and periphery. Originally mischaracterized as an opioid receptor, the sigma-1 receptor binds a vast number of synthetic compounds but does not bind opioid peptides; it is currently considered an orphan receptor. The sigma-1 receptor pharmacophore includes an alkylamine core, also found in the endogenous compound N,N-dimeth...

Sigma receptors are putative targets for neuroprotection following ischemia; however, little is known on their mechanism of action. One of the key components in the demise of neurons following ischemic injury is the disruption of intracellular calcium homeostasis. Fluorometric calcium imaging was used to examine the effects of sigma receptor activation on changes in intracellular calcium concen...

The interaction between the selective sigma (sigma) receptor agonists and 8-OH-DPAT, a serotonin (5-HT)(1A) receptor agonist, was examined in the forced swimming test in rats. The results indicate that joint administration of DTG (5 mg/kg) or SA4503 (3 mg/kg), the selective sigma(1)/sigma(2)- or sigma(1)-receptor agonists, respectively, and 8-OH-DPAT (0.1 or 0.3 mg/kg) induces an antidepressant...

Six sigma has long been used as an effective way to restructure a company’s management process. A number of successful cases have been reported of six-sigma-based management activities dramatically enhancing a company’s strategic performance over study periods of several years. However, while there are abundant case studies in the literature regarding six sigma, there is a lack of empirical stu...

Purpose – Six Sigma has been part of our business lexicon for more than a decade. Debates on its emergence as a strategic initiative have created critics who consider it as an old wine in a new bottle. Is Six Sigma a management fad? This article presents some common myths and realities of Six Sigma business strategy. The paper provides an excellent resource for those people who would like to kn...

sigma(70) subunit is thought to be released from the core RNA polymerase (RNAP) upon the transition from initiation to elongation or shortly afterward. Here, we identify a population of RNAP from E. coli that retains sigma(70) throughout elongation. The relative amount of this population appears to depend on cellular growth and reaches its maximum during the stationary phase. The proportion of ...