Estrogen plays a key regulatory role in a number of biological processes and, in addition to its classic function as a sex hormone, it has been linked to neurodegenerative diseases, including Alzheimer's disease (AD) (Wickelgren, 1997; Brann et al., 2007; Zhang et al., 2007). However, long-term compliance with estrogen therapy is often estimated to be no more than 15%–40%, due to its undesirabl...

rEFErENcES Farlow a et al (2010) PLoS Genetics 6: e1000819 He F et al (1993) Proc Natl Acad Sci USA 90: 7034–7038 isken O, Maquat LE (2007) Genes Dev 21: 1833–1856 Jaillon O et al (2008) Nature 451: 359–362 Mekouar M et al (2010) Genome Biol 11: r65 Mitrovich QM, anderson p (2000) Genes Dev 14: 2173–2184 Sayani S et al (2008) Mol Cell 31: 360–370 Senapathy p (1988) Proc Natl Acad Sci USA 85: 11...

The design and use of PID controllers is a part of what has been denominated Classical Control, which as the name implies, has been studied for many years (DiStefano et al. 1996), however it continues to be a source for research (Alvarez et al. 2008), (Ang et al. 2008), (Su et al. 2010). The structure of the controller contains a differential term to aid in the reduction of system friction and ...

The hippocampus plays a central role to form new episodic memory in various species in‐ cluding humans (Scoville and Milner, 1959). The hippocampal neurons seem to process vari‐ ety of information, such as spatial location (Wills et al., 2010), temporal information (Mitsushima et al., 2009), and emotional state (Chen et al., 2011) within specific episodes (Komorowski et al., 2009; Gelbard-Sagiv...

Excessive alcohol consumption causes 75,000 deaths each year in the United States, and it is the third leading preventable cause of death. Binge drinking accounts for more than half of these deaths (CDC, 2004). Binge drinking is quite prevalent in Korea. According to The Third Korea National Health and Nutrition Examination Survey in 2005, 46.3 % of male adults were heavy drinkers in Korea (Lee...

As known, one of main causes that which induce many damages of machinery, equipment is undesirable vibrations. Particularly, vibrations that occur in low frequency regions (<5Hz) are almost harmful and dangerous to human health and activity researched by (Paddan, 2002). Thus, suspensions are widely used to lengthen the service life of the machinery, equipment as well as to provide more comforta...

To our knowledge, for the first time, we demonstrate that induced pluripotent stem cells (iPSCs) can autonomously generate full-term mice via tetraploid blastocysts complementation. Differentiated somatic cells can be reprogrammed into iPSCs by forced expression of four transcription factors—Oct4, Sox2, Klf4, and c-Myc. However, it has been unclear whether reprogrammed iPSCs are fully pluripote...

part of its information-gathering activity. The views, conclusions, and recommendations are not intended to represent the views of the Commission. part of its information-gathering activity. The views, conclusions, and recommendations are not intended to represent the views of the Commission. Disclaimer This is a working paper of the World Commission on Dams-the report published herein was prep...

Three new species of the spider genus Philoponella Mello-Leitão, 1917 are described: Philoponella opelli n. sp. from Brazil and Ecuador, and Philoponella fluviidulcifis n. sp. , and Philoponella duopunctata n. sp. from Brazil. New records for Philoponella vittata (Keyserling, 1881), P. republicana (Simon, 1891), P. fasciata (Mello-Leitão, 1917) and P. divisa Opell, 1979 are provided for Brazil ...

J. J. Flint, B. Hansen, S. Portnoy, C. H. Lee, M. A. King, M. Fey, F. Vincent, P. Vestergaard-Poulsen, and S. J. Blackband Neuroscience, University of Florida, Gainesville, Fl, United States, McKnight Brain Institute, University of Florida, Gainesville, Fl, United States, Center for Functionally Integrative Neuroscience, University of Aarhus, Aarhus, Denmark, Electrical Engineering, University ...