A new continuous regularized Gauss-Newton-type method with simultaneous updates of the operator (F (x(t))F (x(t)) + ε(t)I) for solving nonlinear ill-posed equations in a Hilbert space is proposed. A convergence theorem is proved. An attractive and novel feature of the proposed method is the absence of the assumptions about the location of the spectrum of the operator F (x). The absence of such ...

Functional multineuron calcium imaging (fMCI) is a large-scale optical recording technique that monitors the spatiotemporal pattern of action potentials, all at once, from large neuron populations. fMCI has unique advantages, including: (i) simultaneous recording from >1000 neurons in a wide area, (ii) single-cell resolution, (iii) identifiable location of neurons and (iv) detection of non-acti...

DNA double strand breaks (DSBs) are the most dangerous form of DNA damage and need to be repaired efficiently in order to maintain genomic stability. The kinase ATM becomes activated upon recognition of DSBs and transduces this into cell cycle checkpoint activation and DNA repair. There are two main pathways by which DSBs can be repaired: Non-homologous end joining (NHEJ) and homologous recombi...

Submega-sized regions of the Bacillus subtilis genome were cloned to plasmid by the B. subtilis Recombinational Transfer (BReT) method. BReT efficiency depends not only on the genome location but also on the choice of sequences for simultaneous homologous recombination during BReT. In an extreme case, a 91-kb region that was unsuccessful on the first attempt was obtained when the slightly shift...

We investigate experimentally the impact of continuous time on a four-player Hotelling location game. The static pure strategy Nash equilibrium (NE) consists of firms paired-up at the first and third quartiles of the linear city. In repeated simultaneous move games (discrete time grid), we fail to obtain convergence to this distinctive NE, as have previous studies. However, with asynchronous mo...

This contribution presents a method for the simultaneous economic optimization and optimal design for disturbance rejection of discrete time systems. The method is an extension of a previously presented approach for the optimization of discrete time systems with constraints on robust stability [10]. In this contribution we extend the method to a new set of constraints on the location of poles o...

This paper presents a new approach to the problem of simultaneous location and segmentation of object in images. The main emphasis is done on the information provided by the contour fragments present in the image. Clusters of contour fragments are created in order to represent the labels defining the different parts of the object. An unordered probabilistic graph is used to model the objects, w...

The main management challenge in coastal aquifers is to prevent saltwater intrusion, ensuring ample freshwater supply. Saltwater intrusion happens due unregulated pumping from production wells. Therefore, it essential have an effective policy, which ensures the requisite amount of be withdrawn without causing intrusion. A methodology for optimizing well locations and maximizing wells presented ...

At the request of the American Joint Committee on Cancer (AJCC), non-anatomic (non-TNM) classifications were evaluated and important classifications incorporated into staging recommendations for oesophageal cancer in the 7th edition of the Cancer Staging Manual [1]. Cancer location, histopathological cell type and histological grade were demonstrated to enhance cancer staging [2]. Adenocarcinom...