نتایج جستجو برای: single point mutation
تعداد نتایج: 1576603 فیلتر نتایج به سال:
Receptor protein-tyrosine kinases (RPTKs) are tightly regulated during normal cellular processes including cell growth, differentiation, and metabolism. Recently, a RPTK-like molecule named novel oncogene with kinase-domain (NOK) has been cloned and characterized. Overexpression of NOK caused severe cellular transformation as well as tumorigenesis and metastasis in nude mice. In the current stu...
Der G-Protein-gekoppelte Adenosin-A2A-Rezeptor (A2AAR) stellt eine wichtige neue (potentielle) Arzneistoff-Zielstruktur für die Immunonkologie und neurodegenerative Erkrankungen dar. Preladenant dessen Derivate gehören zu den wirksamsten A2AAR-Antagonisten mit außerordentlich hoher Selektivität. Kristallstrukturen des humanen A2AARs wurden bereits gelöst, meist unter Verwendung A2A-StaR2-Protei...
background: this study investigated the association between pfcrt, t76 allele and chloroquine resistance in patients with falciparum malaria. molecular assays for point mutations on drugs resistance-related genes are applied tools for monitoring emerging resistance and surveillance malaria control strategies in endemic areas. the mutant genotype at codon 76 of plasmodium falciparum chloroquine ...
Background and Aim: FLT3 gene is a member of class III receptor Tyrosine Kinase, which is expressed in most patients with acute myeloid leukemia (AML). Mutations of FLT3 such as Internal Tandem Duplication (ITD) and point mutation of the D835 are the most common genetic defects in myeloid leukemia. These two mutations in patients with MLA and their effect on survival rate were studied for the f...
background antibiotic resistance is a major therapeutic problem in patients infected with helicobacter pylori. h. pylori clarithromycin resistant mutants have been evolved during antibiotic therapy, this is mainly due to 23s rrna point mutations. objectives in the present study, we investigated anti-mutational features of four traditionally iranian medicinal plants on three local isolated h. py...
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