A new series of imidazo[2,1-b]thiazole analogs containing a methyl sulfonyl COX-2 pharmacophore was synthesized and evaluated for their COX-2 inhibitory activity. According to in-vitro COX-1/COX-2 inhibition data, all compounds (6a-g) were selective inhibitors of COX-2 isoenzyme with IC50 values in the highly potent 0.08-0.16 mM range. These results indicated that both potency and selectivity o...

In many terrestrial ecosystems plant productivity is limited by the availability of mineral nitrogen, which is produced by soil microbial transformations of organic N in soil organic matter (SOM-N). Mineral N availability results from two opposing processes, 1) gross mineral N production (gross ammonification/ gross nitrification) and 2) microbial N immobilization. These processes can be influe...

In his survey paper on branching programs, Razborov Raz91] asked the following question: Does every rectiier-switching network computing the majority of n bits have size n 1++(1) ? We answer this question in the negative by constructing a simple oblivious branching program of size O n log 3 n log log n log log log n ! for computing any threshold function. This improves the previously best known...

The n-tuple of Laplacian characteristic values of a graph is majorized by the conjugate sequence of its degrees. Using that result we find a collection of general inequalities for a number of Laplacian indices expressed in terms of the conjugate degrees, and then with a maximality argument, we find tight general bounds expressed in terms of the size of the vertex set n and the average degree dG...

Bell's degree-variance Var$!{}_{B}$ for a graph $G$, with the degree sequence ($d_1,d_2,cdots,d_n$) and size $m$, is defined as$Var!_{B} (G)=frac{1}{n} sum _{i=1}^{n}left[d_{i} -frac{2m}{n}right]^{2}$.In this paper, a new version of the irregularity measures of variance-type, denoted by $Var_q$, is introduced and discussed. Based on a comparative study, it is demonstrated that the n...

ovarian follicle response and corpus luteum formation following induction of ovulation using gonadotropin-releasing hormone (gnrh) analogues and luteinizing hormone (lh) in bactrian camel were characterized. bactrian camels with a mature follicle (13-19.6 mm) received: 1) natural porcine lh (25 mg, iv, n = 4), 2) buserelin (20 μg, iv, n = 4) and 3) alarelin (25 μg, im, n = 4). daily ultrasonogr...

in this work, the effect of ligand's length on interaction energy of six oximes, a [2-(hydroxyimino)-n-((1-(2-(2-((hydroxyimino)methyl)-1h-imidazol-1-yl)ethyl)-1h-1,2,3-triazol-4-yl)methyl)acetamide], b [2-(hydroxyimino)-n-((1-(3-(2-((hydroxyimino)methyl)-1h-imidazol-1-yl)propyl)-1h-1,2,3-triazol-4-yl)methyl)acetamide], c [2-(hydroxyimino)-n-((1-(4-(2-((hydroxyimino)methyl)-1h-imidazol-1-y...

In this paper we present two eecient algorithms for general preex computations (GPC, for sort) on meshes with multiple broadcasting and reconngurable meshes respectively. On a mesh with multiple broadcasting of size n n, the GPC problem of size kn (1 k n) can be solved in O(log n) time if k = 1, and in O(k log n log k) time if 2 k n. On a reconngurable mesh of size n n, the GPC problem of size ...

Soil carbon and nitrogen contents play an important role in sustaining soil physical and chemical quality and help to have healthy environments. The continues conversion of rangelands to arable lands has the potential to change carbon and nitrogen sequestration. In this study to evaluate the effects of land use change on soil organic carbon and nitrogen stock, forty samples collected from north...

It is shown that every tree of size n over a fixed set of σ different ranked symbols can be decomposed into O( n logσ n ) = O(n log σ log n ) many hierarchically defined pieces. Formally, such a hierarchical decomposition has the form of a straight-line linear context-free tree grammar of size O( n logσ n ), which can be used as a compressed representation of the input tree. This generalizes an...