A new steroid, itesmol 3-O-palmitate (1), along with two known steroids were isolated from the trunk of Berberis koreana. The structure of 1 was determined on the basis of spectroscopic analyses involving 2D NMR and chemical reactions. Compound 1 exhibited potential antiproliferative activity against A549, SK-OV-3, SK-MEL-2, and HCT-15 cell lines (respective IC(50) values of 7.41, 9.20, 4.53, a...

A [ An−1 + p1A n−2 + · · ·+ pn−1 In ] = −pn In . Since A is nonsingular, pn = (−1)n det(A) 6= 0; thus the result follows. Newton’s Identity. Let λ1, λ2, . . . , λn be the roots of the polynomial K(λ) = λ + p1λ n−1 + p2λ n−2 + · · · · · ·+ pn−1λ+ pn. If sk = λ k 1 + λ k 2 + · · ·+ λn, then pk = − 1 k (sk + sk−1 p1 + sk−2 p2 + · · ·+ s2 pk−2p1 + s1 pk−1) . Proof. From K(λ) = (λ − λ1)(λ − λ2) . . ...

1) Institute of Botany, Slovak Academy of Sciences, Dúbravská cesta 14, SK-845 23 Bratislava, Slovakia (*corresponding author’s e-mail: [email protected]) 2) Department of Phytology, Faculty of Forestry, Technical University of Zvolen, Masarykova 24, SK-960 53 Zvolen, Slovakia 3) Department of Natural Environment, Faculty of Forestry, Technical University of Zvolen, Masarykova 24, SK-960...

Sphingolipid metabolism is driven by inflammatory cytokines. These cascade of events include the activation of sphingosine kinase (SK), and subsequent production of the mitogenic and proinflammatory lipid sphingosine 1-phosphate (S1P). Overall, S1P is one of the crucial components in inflammation, making SK an excellent target for the development of new anti-inflammatory drugs. We have recently...

Small-conductance calcium-activated potassium (SK) channels play an important role in regulating neuronal excitability. While SK channels at the soma have long been known to contribute to the medium afterhyperpolarization (mAHP), recent evidence indicates they also regulate NMDA receptor activation in dendritic spines. Here we investigate the activation of SK channels in spines and dendrites of...

BACKGROUND Wilms tumor (WT) is an embryonic kidney cancer, for which histone acetylation might be a therapeutic target. LBH589, a novel targeted agent, suppresses histone deacetylases in many tumors. This study investigated the antitumor activity of LBH589 in SK-NEP-1 and G401 cells. METHODS SK-NEP-1 and G401 cell growth was assessed by CCK-8 and in nude mice experiments. Annexin V/propidium ...

Ca+-activated small-conductance K+ (SK) channels play a fundamentally important role in all excitable cells. They are potassium selective, voltage-insensitive and are activated by increases in the levels of intracellular Ca+ such as occur during an action potential (Zhang et al., 1995; Kohler et al., 1996; Sah et al., 1991; Lorenzen et al., 1992). As the action potential decays, the membrane po...

Loss of vital functions in the somatic motor and sensory nervous systems can be induced by severe peripheral nerve transection with a long gap following trauma. In such cases, autologous nerve grafts have been used as the gold standard, with the expectation of activation and proliferation of graft-concomitant Schwann cells associated with their paracrine effects. However, there are a limited nu...

RATIONALE Ca(2+)-activated K(+) channels are present in a wide variety of cells. We have previously reported the presence of small conductance Ca(2+)-activated K(+) (SK or K(Ca)) channels in human and mouse cardiac myocytes that contribute functionally toward the shape and duration of cardiac action potentials. Three isoforms of SK channel subunits (SK1, SK2, and SK3) are found to be expressed....