Rosacea is a common skin condition that affects an estimated 13 million Americans, with almost half of these patients between the ages of 30 and 50 years old [1]. It is a relapsing, chronic dermatosis that develops in stages and is characterized by a defect in vascular responsiveness [2,3]. Most often, fair-skinned individuals are seen first with flushing and blushing episodes followed by persi...

Apart from gastroenteritis, rotavirus has been rarely implicated with some cutaneous disorders such as generalized maculo-papular exanthema, infantile acute hemorrhagic edema and Gianotti-Crosti syndrome. We report a 30-month old toddler boy who developed erythematous macular skin eruptions during the course of rotavirus gastroenteritis. To our knowledge, this is the first case in the literatur...

Non-traumatic stereotyped postictal purpura is rare. A 25-year-old woman presented with right facial, cheek and periorbital purpuric eruptions that occurred after secondarily generalized tonic-clonic seizures. The stereotyped, invariably right-sided facial skin eruption, which resolved in 48 hours, falsely raised concerns of spousal abuse. Possible pathophysiological mechanisms include: (a) val...

Coccidioidomycosis occurs in arid and semi-arid regions of the New World from the western United States to Argentina. Highly endemic areas are present in the southwest United States. Coccidioides species live in the soil and produce pulmonary infection via airborne arthroconidia. The skin may be involved by dissemination of the infection, or by reactive eruptions, such as a generalized exanthem...

creasing attention as an important enteric pathogen. In many developed countries, it has surpassed Shigella and now rivals Salmonella and Campylobacter as a cause of acute gastroenteritis. A number of characteristic factors related to virulence enable Y. enterocolitica to produce a wide spectrum of clinical manifestations, ranging from potentially fatal bacteremia and “pseudoappendicitis” to sk...

One hundred and thirty-two patients with rheumatoid arthritis treated with gold have been studied for possible associations between HLA DR antigens and different adverse reactions occurring during such therapy. Patients possessing HLA DR3 had a significantly greater frequency of side effects than patients lacking this antigen. It was particularly noticed that DR3 positive patients on gold treat...

Incontinentia pigmenti (IP) (OMIM #308300) is a rare X-linked dominant neuroectodermal multisystemic syndrome due to mutations in the gene for NF-κB essential modulator (NEMO). A term newborn girl who was born with erythematous vesicular eruptions developed recurrent seizures during the first and second weeks of her life. The serial MRIs demonstrated diffuse, progressive brain infarctions and s...

Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) syndrome is associated with severe skin eruptions, fever, hematological abnormalities, and multi-organ involvement. Although aromatic anticonvulsant drugs have been frequently associated with the manifestation of DRESS syndrome, its induction following treatment with nonaromatic anticonvulsants, such as valproate, has rarely been rep...

Imiquimod is an immunomodulator with both antitumor and antiviral properties. It is currently available in two cream formulations as Aldara (imiquimod 5%) and the newly approved Zyclara (imiquimod 3.75%). Imiquimod has been associated with localized erythema, crusting, and scaling at the site of application. However, more severe generalized skin eruptions including erythema multiforme, psoriasi...

Psoriasis vulgaris is an inflammatory papulosquamous and koebner positive disease of the skin. The isotopic (koebner) response, a result of secondary dermatitis, is unrelated with former recovery of dermatitis. Although first reported by Wolf et. al (1) with a series of 58 patients, koebnerization resulting from Herpes Zoster infection is extremely rare in the current literature. A 74-year-old ...