The glucagonoma syndrome is characterized by dermatitis, glucose intolerance, hypoaminoacidemia, and hyperglucagonemia secondary to an alpha-cell tumor of the pancreas. The classical symptoms are associated with alpha-cell pancreatic islet cell tumor or 'glucagonoma'. Other clinical features include anemia, glossitis, and weight loss. A 65-year-old woman with the syndrome came for medical atten...

Introduction. Lyme disease is an emerging worldwide infectious disease with major foci of endemicity in North America and regions of temperate Eurasia. The erythema migrans rash associated with early infection is found in approximately 80% of patients and can have a range of appearances including the classic target bull's-eye lesion and nontarget appearing lesions. Methods. A survey was designe...

We report a patient with Chagas' disease that presented Trypanosoma cruzi reactivation after cardiac transplantation and immunodepression, characterized by skin lesions of erythema nodosum. This is an unusual presentation of Chagas' disease.

A skin lesion previously unassociated with Crohn's disease is described. Although superficially resembling erythema nodosum it runs a different clinical course and has different histological appearances, the central feature being necrobiotic collagen. The term ;nodular necrobiosis' is suggested.

A case of acute sarcoidosis associated with the simultaneous appearance of cutaneous leucocytoclastic vasculitis and erythema nodosum is reported. Circulating immune complexes were demonstrated and may have been important in the pathogenesis of both types of skin lesion.

Necrolytic migratory erythema is an obligatory paraneoplastic syndrome. Here we describe a patient with a neuroendocrine tumor of probably pancreatic origin. She developed the typical skin lesions under chemotherapy with temozolomide and capecitabine.

Background: Melasma is a common disorder of hyperpigmentation affecting millions of people worldwide. All the exact pathways to understand the complete pathogenesis of melasma is unknown. Aims: To determine the biophysical characteristics of melasma skin compared to the normal surrounding skin. Methods: Thirty-six patients with melasma were recruited in this case-control study. The subtype of m...

The protective effect of isoflavones on skin damage from ultraviolet (UV) radiation and their bioavailability were investigated in ovariectomized hairless mice fed diets composed of fermented soymilk containing aglycone forms of isoflavones or control soymilk containing glucose-conjugated forms of isoflavones. The erythema intensity of dorsal skin was significantly higher in ovariectomized mice...