OBJECTIVES To compare periodontal findings in systemic lupus erythematosus (SLE) patients and healthy controls, and to determine, whether there is a correlation between periodontal parameters and SLE biomarkers. METHODS This cross-sectional study was conducted in the Faculty of Dentistry, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia between November 2012 and February 2014. Twent...

To demonstrate the mechanisms of the curative effect of Saussurea lappa ethanol extract (SLE) against prostate cancer, we evaluated the effect of SLE on the induction of apoptosis and autophagy and investigated whether SLE-induced autophagy exerts a pro-survival or pro-apoptotic effect in lymph node carcinoma of the prostate (LNCaP) prostate cancer cells. SLE was prepared using 100% ethanol and...

Objective: We investigated the levels of cerebrospinal fluid (CSF) interleukin 8 (IL-8) in neuropsychiatric manifestations in systemic lupus erythematosus (NP-SLE). Methods: CSF samples were obtained from 48 SLE patients (35 patients with diffuse psychiatric/ neuropsychological syndromes [diffuse NP-SLE] and 13 patients with neurologic syndromes or peripheral neuropathy [focal NP-SLE]) as well ...

Accumulating data indicate that metabolic syndrome is an inflammatory condition. Systemic lupus erythematosus (SLE) is an autoimmune disorder associated with nephritis and cardiovascular disease. Evidence suggests that individuals with SLE are at risk for developing insulin resistance; however, this has not been directly examined. Using an established mouse strain with SLE (NZBWF1), we examined...

Cardiovascular disease (CVD) is a major cause of death in systemic lupus erythematosus (SLE) patients. Although the risk for cardiovascular events in patients with SLE is significant, the absolute number of events per year in any given cohort remains small. Thus, CVD risks stratification in patients with SLE focuses on surrogate markers for atherosclerosis at an early stage, such as reduced ela...

Patienten mit systemischem Lupus erythematodes (SLE) stellen im Hinblick auf das SARS-CoV-2 Infektionsrisiko und assoziierten Folgen eine besonders gefährdete Bevölkerungsgruppe dar. Daten liefern Hinweise, dass COVID-19 SLE ein hohes Risiko für Krankenhausaufenthalte neue SLE-Schübe aufweisen. Izmirly et al. untersuchten die Seroreaktivität Auftreten von Krankheitsschüben nach einer COVID-19-I...

Systemic lupus erythematosus (SLE) is a complex autoimmune disease and occurs worldwide in both children and adults. The estimated annual incidence among children is 2.22/100,000 and among adults is 23.2/100,000 in the United States. There is increasing understanding about differences in disease manifestations, medication use, and disease severity between those with childhood-onset SLE as compa...

Systemic lupus erythematosus (SLE) predominantly affects women of childbearing age, and the management of pregnant patients with SLE is challenging because pregnancy can aggravate SLE and vice versa. Furthermore, the drugs used to treat SLE can adversely affect the fetus. Accordingly, pregnancy should be planned in advance in women with lupus, and careful planning and treatment are required to ...

Coronary artery disease is the most important cause of mortality in patients with systemic lupus erythematous (SLE). After stenting for coronary artery disease in SLE patients similar to non-SLE patients, the risk of stent thrombosis is always present. Although there are reports of stent thrombosis in SLE patients, very late recurrent stent thrombosis is rare. We experienced a case of very late...

We prove that the outer boundary of the final hull of some chordal SLE(κ; ~ ρ) process has the same distribution as the image of some chordal SLE(κ; ~ ρ′) trace, where κ > 4 and κ = 16/κ; and the reversal of some SLE(4; ~ ρ) trace has the same distribution as the time-change of some SLE(4; ~ ρ′) trace. And we also study some geometric properties of some chordal SLE(κ; ~ ρ) traces.