نتایج جستجو برای: sledai
تعداد نتایج: 798 فیلتر نتایج به سال:
OBJECTIVE The objective of this article is to evaluate the safety and clinical outcome of rituximab treatment in systemic lupus erythematosus (SLE) patients refractory to standard of care therapy in a real-life setting in Germany. METHODS The GRAID registry included patients with different autoimmune diseases who were given off-label treatment with rituximab. Data on safety and clinical respo...
To determine the expression of mTOR, Becline-1, LC3 and p62 in the peripheral blood mononuclear cells (PBMCs) of systemic lupus erythematosus (SLE) and assess their relationship with disease activity and immunologic features. The expression of mTOR, Becline-1, LC3 and p62 was detected by RT-PCR in 81 SLE subjects and 86 age- and sex-matched healthy controls. Data regarding demographics and clin...
Case presentation: L.S.O., female, 15 years old, hospitalized for peaks of fever, anemia, positive direct coombs, hypocomplementemia and proteinuria >0.5 g/24h. Pulse therapy with methylprednisolone was prescribed the hypothesis systemic lupus erythematosus (SLE). Evolved severe headache convulsive crises presenting cortical, subcortical, posterior bilateral hypodensity on cranial tomography. P...
Abstract Background and Aims Lupus nephritis (LN) is a severe renal manifestation of systemic lupus erythematosus (SLE) that negatively impacts morbidity mortality; however, real-world data for LN scarce. This study describes: the proportion patients with SLE managed by rheumatologists (rheum-managed) nephrologists (neph-managed) class III–V; Safety Estrogens in Erythematosus National Assessmen...
زمینه و هدف: تحقیقات اخیر نشان داده اند که پرولاکتین می تواند نقشی در پاتوژنز بیماری لوپوس ( systematic lupus erythematosus= sle ) داشته باشد. این هورمون پپتیدی با تحریک سیستم ایمنی می تواند باعث تشدید فعالیت بیماری لوپوس گردد. هدف از این تحقیق نشان دادن رابطه سطح پرولاکتین سرم و میزان فعالیت بیماری لوپوس است. روش کار: این مطالعه توصیفی ـ تحلیلی بر روی 35 بیمار مبتلا به لوپوس که به صورت تصادفی ...
background: recent accumulated evidence suggests that prolactin (prl) is an important immunomodulator and plays an important role in the pathogenesis of systemic lupus erythematosus (sle). the current study aimed to compare hyperprolactinemia frequency and evaluate its possible association with lupus activity in sle patients in zahedan. methods: in a case-control study we determined serum prola...
Objective: To evaluate the effects of rituximab versus mycophenolate mofetil or cyclophosphamide as control in lupus nephritis by meta-analysis. Methods: A systematic search was carried out up to January 2022, obtaining 7 studies involving 645 participants with at commencement investigation; 198 them were treated rituximab, while 447 cyclophosphamide. We determined odds ratio (OR) and mean diff...
OBJECTIVES To determine the safety of and immunogenicity induced by A/H1N1 influenza vaccination in patients with systemic lupus erythematosus (SLE). RESEARCH DESIGN AND METHODS The study population comprised 21 SLE patients and 15 healthy control subjects who underwent split-virion, inactivated monovalent A/H1N1 vaccination between December 2009 and January 2010. Sera were obtained before, t...
OBJECTIVE To define the pattern of disease expression and to gain better understanding in patients with juvenile onset systemic lupus erythematosus (SLE) in Portugal. METHODS The features of unselected patients with systemic lupus erythematosus who had disease onset before the age of 18 years were retrospectively analysed in three Portuguese centres with Pediatric Rheumatology Clinic over a 2...
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