PET is used in laboratory small-animal research to visualize and track certain molecular processes associated with diseases such as cancer, heart disease, and neurologic disorders in living small-animal models of disease. The current and next generation of PET molecular imaging probes, assays, and imaging systems still have substantial room to improve PET's ability to detect, visualize, and qua...

We have recently introduced the idea of making use of three-photon positron annihilations in positron emission tomography. In this paper the basic characteristics of the three-gamma imaging in PET are studied by means of Monte Carlo simulations and analytical computations. Two typical configurations of human and small animal scanners are considered. Three-photon imaging requires high energy res...

The need to study dynamic biologic processes in intact small-animal models of disease has stimulated the development of high-resolution nuclear imaging methods. These methods are capable of clarifying molecular interactions important in the onset and progression of disease, assessing the biologic relevance of drug candidates and potential imaging agents, and monitoring therapeutic effectiveness...

Advances in conformal radiation therapy and advancements in pre-clinical radiotherapy research have recently stimulated the development of precise micro-irradiators for small animals such as mice and rats. These devices are often kilovolt x-ray radiation sources combined with high-resolution CT imaging equipment for image guidance, as the latter allows precise and accurate beam positioning. Thi...

PURPOSE Magnetic resonance imaging (MRI) of rodents can be expected to be a growing application, particularly when translatory imaging research "from mouse to man" is envisioned. 7 T high-field human whole-body MR systems provide a powerful platform for high-resolution small animal imaging. For achieving adequate spatial resolution, dedicated radiofrequency coils have to be designed to provide ...