Staphylococcus aureus is known to generate small colony variants (SCVs) that are resistant to aminoglycoside antibiotics and can cause persistent and recurrent infections. The SCV phenotype is unstable, and compensatory mutations lead to restored growth, usually with loss of resistance. However, the evolution of improved growth, by mechanisms that avoid loss of antibiotic resistance, is very po...

In a recent multicenter study, we determined the prevalence (cross-sectional) and persistence of mucoid Staphylococcus aureus in people with cystic fibrosis (pwCF) one-year prospective study: from 41 451 S. aureus-positive pwCF 13 centers (9.1%) was cultured (unpublished observation). SCVs have been shown to be associated more severe lung disease. It is not known whether isolates also exhibit s...

introduction: endothelial progenitor colony forming unit-endothelial cells (cfu-ec) were first believed to be the progenitors of endothelial cells, named endothelial progenitor cells. further studies revealed that they are monocytes regulating vasculogenesis. the main hindrance of these cells for therapeutic purposes is their low frequency and limited replicative potentials. this study was unde...