The intestinal epithelium serves as an essential barrier to the outside world and is maintained by functionally distinct populations of rapidly cycling intestinal stem cells (CBC ISCs) and slowly cycling, reserve ISCs (r-ISCs). Because disruptions in the epithelial barrier can result from pathological activation of the immune system, we sought to investigate the impact of inflammation on ISC be...

NHERF1/EBP50, an adaptor molecule that interacts with β-catenin, YAP, and PTEN, has been recently implicated in the progression of various human malignancies, including colorectal cancer. We report here that NHERF1 acts as a tumor suppressor in vivo for intestinal adenoma development. NHERF1 is highly expressed at the apical membrane of mucosa intestinal epithelial cells (IECs) and serosa mesot...

abstract bowel obstruction is a known complication after bariatric surgery especially roux-en-y gastric bypass. the known etiologies include internal hernia, jejunojejunostomy stricture, ileus, intussusceptions, superior mesenteric artery syndrome, incarcerated port site hernia, and adhesions. blood clot is a rare cause of small intestinal obstruction after laparoscopic roux-en-y gastric bypass...

a 41-year old mentally retarded patient presented acutely with a 3 day history of vomiting and absolute constipation.  intestinal obstruction was diagnosed following an abdominal x ray. at laparotomy, a left paraduodenal hernia was present, without incarceration of small bowel. the herniated loops were reduced and the hernia orifice closed. the anatomy, treatment and importance of considering t...

The persistent activation of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway is oncogenic and involved in colorectal neoplasia. Mutations of both regulatory subunit and catalytic subunit of PI3K have been demonstrated in colon cancers. In the present study, we show that heterozygous disruption of the phosphatase and tensin homolog (PTEN) tumor suppressor gene promoted tumor progression in ...

To study clinical and histopathological changes occur within the first 12 hours of strangulating obstruction of the small intestine in equine, twenty five adult donkeys were used in an experimental study. Strangulation obstruction of the small intestine was performed for 3, 6, 9 and 12 hours, respectively. Clinical examination was done before surgery and at 3 hours intervals postoperatively. Af...

SUMMARY Askin tumor is a peripheral neuroepithelioma originating in chest wall. It is a very aggressive tumor and with Ewing's sarcoma are the most frequent tumors of chest wall. The tumor is composed of small round or ovoid cells arranged in sheets with pseudorossette formation. Some times around vessels, glycogen staining is some times positive in H & E but always positive in E.M. In E.M be...