BACKGROUND Implant-related infections represent one of the most severe complications in orthopaedics. A fast-resorbable, antibacterial-loaded hydrogel may reduce or prevent bacterial colonization and biofilm formation of implanted biomaterials. QUESTIONS/PURPOSES We asked: (1) Is a fast-resorbable hydrogel able to deliver antibacterial compounds in vitro? (2) Can a hydrogel (alone or antibact...

A novel hydrogel, based on an alginate/hyaluronate mixture and Ce(III) ions, with effective bioactive and antimicrobial ability was developed to be used as vehicle of a synthetic bone substitute producing an injectable substitute (IBS). Firstly, three different IBSs were prepared using three developed alginate-based hydrogels, the hydrogel Alg composed by alginate, the hydrogel Alg/Ch composed ...

BACKGROUND The periodontitis is one of the most prevalent diseases with alveolar resorption in adult people and is the main cause of the tooth loss. To investigate the possibility for protecting the loss of alveolar bone in periodontal diseases, a RNAi-based therapeutic strategy is applied for silencing RANK signaling using thermosensitive chitosan hydrogel as siRNA reservoir and vector. RESU...

Purpose Sustained release hydrogel with bupivacaine (AnestaGel™) is a novel formulation of extended release bupivacaine in a biohydrogel Matrix™. We sought to compare the analgesic effects via mechanical allodynia, the pharmacokinetic characteristics via serum blood levels, and the local tissue effects via pathology, following injection of either sustained release hydrogel with bupivacaine, lip...

BACKGROUND Hydrogel and silicone-hydrogel polymeric materials are widely used in ophthalmology for the manufacture of contact lenses. An important aspect is the investigation of the structure of these materials. OBJECTIVES This study has been conducted in order to compare the degree of disorder and presence of free volumes in the internal structure of the polymeric soft contact lenses Omafilc...

Conductive hydrogel combined with Ag/AgCl electrode is widely used in the acquisition of bio-signals. However, the high adhesiveness of current commercial hydrogel causes human skin allergies and pruritus easily after wearing hydrogel for electrodes for a long time. In this paper, a novel conductive hydrogel with good mechanical and conductive performance was prepared using polyvinyl alcohol (P...

existed electricity grids deliver produced power to the consumer passing through transmission and distribution grids. according to high losses of these grids in transmission level and inexistence of bilateral interaction for simultaneous information exchange, a concept of smart grids were made by capabilities such as consciously participation of consumers in the smart electricity grids, an amou...

in this work, hydrogel nanocomposites were synthesized by solution polymerization of acrylic acid (aa) and itaconic acid (ia) in the presence of cotton fabric. ammonium persulfate (aps) was used as the polymerization initiator in the presence of a crosslinker, methylene bisacrylamide (mba). insertion of ag followed by reduction of ag+ cations results in a hydrogel nanocomposite. the structure a...

BACKGROUND To improve the efficacy of bone marrow-derived mesenchymal stem cell (MSC) therapy targeted to infarcted myocardium, we investigated whether a self-setting silanized hydroxypropyl methylcellulose (Si-HPMC) hydrogel seeded with MSC (MSC+hydrogel) could preserve cardiac function and attenuate left ventricular (LV) remodeling during an 8-week follow-up study in a rat model of myocardial...

A polyethylene glycol (PEG) hydrogel sealant recently has been approved as an adjunct to sutured dural closure in Japan. We treated consecutive six patients with PEG hydrogel sealant in posterior fossa operation. Three of six cases suffered delayed cerebrospinal fluid (CSF) leak after watertight dural closure with the PEG hydrogel sealant, although there was no leak case which was treated with ...