nowadays, environment-sensitive smart drug delivery systems have found diverse applications in pharmaceutical science and technology. these systems can respond to the environment stimuli such as temperature, pressure, ph, light, electrical and magnetical fields and etc. they can release the proper amount of drug in human body. among these systems, special attention and much research works have ...

Radiochromic film has become an important tool to verify dose distributions in highly conformal radiation therapy such as IMRT. Recently, a new generation of these films, EBT3, has become available. EBT3 has the same composition and thickness of the sensitive layer of the previous EBT2 films, but its symmetric layer configuration allows the user to eliminate side orientation dependence, which i...

background: normal tissue toxicity continues to remain as a major challenge for radiation oncologists for delivering the total dose to the tumour cells in cancer patients. cellular, molecular and plasma based early biomarkers to predict the overreactions and non-overreactions of normal tissue toxicity before the initiation of radiotherapy can be valuable for personalised treatment. the aim of t...

intraoperative radiation therapy (iort) is a multidisciplinary approach in which residual tumors or tumor beds are directly irradiated during a surgical procedure. to evaluate its efficacy, from 1985, we conducted a prospective study including non-metastatic gastric adenocarcinoma treated by surgery, iort (15 grays) and postoperative external beam radiotherapy (44 grays). up to 1993, 51 cases o...

after curative treatment of hodgkin’s lymphoma, increased risk of certain solid tumors has been reported. to best of our knowledge this is the first report of metachronous pancreatic adenocarcinoma which developed outside the previous radiation field in a patient with relapse hodgkin’s lymphoma. herein we present an 81-year-old female who developed pancreatic adenocarcinoma four years after the...

background: treatment of ionizing radiation combined with chemical agents can enhance the inactivation of cells. the aim of this study was to determine the parameters involved in the inhibition of cell recovery. materials and methods: a mathematical model describing the process of recovery as a decrease in the effective radiation dose was used. the model includes two parameters, recovery consta...

background: diarrhea is a well-recognized side effect associated with pelvic radiation; however, there is not any effective common treatment for radiation-induced diarrhea. a popular alternative is probiotics, which have been used in several gastrointestinal disorders. probiotics are live microbial food supplements. furthermore, honey is a putative nutritional with a variety of health effects, ...

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