While gemcitabine has been the mainstay therapy for advanced pancreatic cancer, newer combination regimens (e.g. FOLFIRINOX) have extended patient survival, though carry greater toxicity. Biomarkers are needed to better stratify patients for appropriate therapy. Previously, we reported that one-third of pancreatic cancers harbor deletions or deleterious mutations in key subunits of the SWItch/S...

In developing of ointment for topical treatment of colds the structural and mechanical properties of the ointment bases contained isopropyl palmitate, beeswax and solid fat in different concentrations have been studied. Amount of isopropyl palmitate 60% remained constant and the ratio of solid fat and bee wax was varied. In order to study thixotropic properties the curve of kinetics deformation...

In this work, silica nanofibers (SNFs) were prepared by an electrospinning method and modified with poly-d-lysine (PDL) or (3-aminopropyl) trimethoxysilane (APTS) making biocompatible and degradable substrates for neuronal growth. The as-prepared SNF, modified SNF-PDL, and SNF-APTS were evaluated using scanning electron microscopy, nitrogen adsorption/desorption isotherms, contact angle measure...

The Drosophila sex determination gene Sex-lethal controls its own expression and the expression of downstream target genes such as transformer by regulating RNA splicing. Genetic and molecular studies have established that Sxl requires the product of another gene, snf, to autoregulate the splicing of its own transcripts. snf has recently been shown to encode a Drosophila U1 and U2 small nuclear...

A systems understanding of nuclear organization and events is critical for determining how cells divide, differentiate, and respond to stimuli and for identifying the causes of diseases. Chromatin remodeling complexes such as SWI/SNF have been implicated in a wide variety of cellular processes including gene expression, nuclear organization, centromere function, and chromosomal stability, and m...

abstract background: multiple sclerosis (ms) is a complex inflammatory disease of the central nervous system. despite extensive research, its exact cause is unknown. one of the roles of nurses is discovery and prevention of factors related to the disease. this study aimed to investigate several food items concerning the etiology of ms in a population of ahvaz (iran). materials and methods: this...

1. Abstract 2. Introduction 2.1. Histone acetyltransferase and deacetylase complexes 2.2. SWI/SNF family of chromatin remodeling complexes 3. Activator targeting of histone acetyltransferase complexes 4. Activator targeting of SWI/SNF complexes 5. Communication between HATs and SWI/SNF at promoter nucleosomes 6. Repressor targeting of histone deacetylase complexes 7. Perspectives 8. Acknowledge...

The aim of this study was to compare the effect of toothpastes containing TiF(4), NaF, and SnF(2) on tooth erosion-abrasion. Bovine enamel and dentin specimens were distributed into 10 groups (n = 12): experimental placebo toothpaste (no F); NaF (1450 ppm F); TiF(4) (1450 ppm F); SnF(2) (1450 ppm F); SnF(2) (1100 ppm F) + NaF (350 ppm F); TiF(4) (1100 ppm F) + NaF (350 ppm F); commercial toothp...

BACKGROUND In Saccharomyces cerevisiae, three out of the four histone gene pairs (HTA1-HTB1, HHT1-HHF1, and HHT2-HHF2) are regulated by the HIR co-repressor complex. The histone chaperone Rtt106 has recently been shown to be present at these histone gene loci throughout the cell cycle in a HIR- and Asf1-dependent manner and involved in their transcriptional repression. The SWI/SNF and RSC chrom...