نتایج جستجو برای: snp309
تعداد نتایج: 201 فیلتر نتایج به سال:
BACKGROUND TP53 mutations have been associated with resistance to anthracyclines but not to taxanes in breast cancer patients. The MDM2 promoter single nucleotide polymorphism (SNP) T309G increases MDM2 activity and may reduce wild-type p53 protein activity. Here, we explored the predictive and prognostic value of TP53 and CHEK2 mutation status together with MDM2 SNP309 genotype in stage III br...
Many of the substances humans are exposed to in the environment pose a health risk. Thus, there is a need to come up with strategies to understand the mechanisms by which toxic substances impair human health. A few animal and human studies have examined the role of sex and sex hormones in toxicology studies. Molecular studies have pointed to sex differences in the metabolism of polycyclic aroma...
The present study aimed to investigate the association of p73 G4C14-A4T14 polymorphism and murine double minute 2 (MDM2) 309 T/G single nucleotide polymorphisms (SNPs) with the risk of developing non-small cell lung cancer (NSCLC) in Sothern China. The p73 and MDM2 genotypes of peripheral blood DNA from 186 patients with NSCLC and 196 normal controls were detected by polymerase chain reaction (...
Approximately 2 300 new cases of urinary bladder carcinoma (UBC) are diagnosed every year in Sweden. This type of cancer is characterized as a long-standing disease with a high risk of recurrence and progression from an indolent to a more aggressive course. UBC occurs in a non-muscle-invasive form (stages Ta and T1), which is treated mainly with local resection and BCG instillation, and a muscl...
سقط خودبخودی را ختم حاملگی قبل از هفته بیستم حاملگی یا تولد نوزادی با وزن کمتر از 500گرم تعریف می کنند. از جمله فاکتورهای شناسایی شده در سقط، آنومالی های کروموزومی والدین، فاکتورهای ایمونولوژیک، بی نظمی های اندوکرین، ناهنجاری های رحمی، عفونت ها، فاکتور های محیطی و ... را می توان نام برد که تقریبا? در 50% سقط ها مشاهده می شوند. علاوه بر این فاکتورها، پلی مورفیسم های ژنی از فاکتورهای موثر در افزا...
The MDM2 proto-oncogene plays a key role in central cellular processes like growth control and apoptosis, and the gene locus is frequently amplified in sarcomas. Two polymorphisms located in the MDM2 promoter P2 have been shown to affect cancer risk. One of these polymorphisms (SNP309T>G; rs2279744) facilitates Sp1 transcription factor binding to the promoter and is associated with increased ca...
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