The present study was carried out with an objective of preparation and in vitro evaluation of floating tablets of hydroxypropyl methyl cellulose (HPMC) and polyethylene oxide (PEO) using ranitidine hydrochloride as a model drug. The floating tablets were based on effervescent approach using sodium bicarbonate a gas generating agent. The tablets were prepared by dry granulation method. The effec...

Purpose The aim of the present narrative review was to consider the evidence on the timing, optimal dose and intake duration of the main dietary supplements β-alanine, nitrate, caffeine, creatine, sodium bicarbonate, carbohydrate and protein. Methods This review article will focuses on timing, optimal dose and intake duration of main dietary supplements for consuming. Results This paper rev...

Previous functional studies have demonstrated that muscle intracellular pH regulation is mediated by sodium-coupled bicarbonate transport, Na+/H+ exchange, and Cl-/bicarbonate exchange. We report the cloning, sequence analysis, tissue distribution, genomic organization, and functional analysis of a new member of the sodium bicarbonate cotransporter (NBC) family, NBC3, from human skeletal muscle...

Introduction: Air-powder polishing devices are increasingly used for stain and plaque removal. However, besides cleaning the tooth surface, they may increase the surface roughness of the dental tissues. This in turn may result in plaque accumulation and superficial degradation. Thus the aim of this study was to assess the influence of three different abrasive agents: Pumice, Sodium bicarbonate ...

INTRODUCTION The purpose of this prospective, randomized, double-blind study was to evaluate the effect of a buccal infiltration of sodium bicarbonate on the anesthetic success of the inferior alveolar nerve block (IANB) for mandibular first molars in patients with symptomatic irreversible pulpitis. METHODS One hundred patients diagnosed with symptomatic irreversible pulpitis of a mandibular ...

The present study describes the hydrochemistry of ground waters found in Mesta River Basin, located south-western part Bulgaria. groundwater’s composition can be expressed as follows: Ca2+ > Na+ Mg2+ K+; K+ equivalent units for cations, and HCO3– SO42– Cl– anions. chemical studied groundwater described calcium-bicarbonate. calcium ions make up from 17.90% to 38.62% (30.18% on average), bicar...

BACKGROUND Patients with infective endocarditis (IE) have an elevated risk of renal dysfunction because of extensive systemic inflammation and use of nephrotoxic antibiotics. In this randomized, placebo-controlled trial, we investigated whether perioperative sodium bicarbonate administration could attenuate postoperative renal dysfunction in patients with IE undergoing cardiac surgery. METHOD...

INTRODUCTION Cardiac-surgery-associated-acute-kidney-injury (CSA-AKI) is associated with increased morbidity and mortality. Recent data from patients undergoing on-pump coronary artery bypass grafting suggest that a perioperative infusion of sodium-bicarbonate may decrease the incidence of CSA-AKI. The present study aims to analyze the renoprotective effects of a 24h infusion of sodium-bicarbon...

A swine producer reported severe chemical skin burns and high death losses when a group of finisher pigs was exposed to a combination of hydrated lime and sodium bicarbonate. Hydrated lime, an alkalinizing agent commonly used in industry and agriculture, is derived from limestone. We report clinical and experimental evidence that sodium bicarbonate can intensify the caustic effects of this form...

Ten intact dogs were subjected to hemodialysis against a solution of lowsodium content to determine the influence of sodium depletion on myocardial binding of digoxin-H. Serial determinations of seaim sodium, potassium, chloride, bicarbonate, pH, and osmolality, of cardiac output, and of cardiac rhythm were obtained in these and in 10 control dogs dialyzed against the standard solution. A dose ...