OBJECTIVES To critically discuss the treatment of metabolic acidosis and the main mechanisms of disease associated with this disorder; and to describe controversial aspects related to the risks and benefits of using sodium bicarbonate and other therapies. SOURCES Review of PubMed/MEDLINE, LILACS and Cochrane Library databases for articles published between 1996 and 2006 using the following ke...

BACKGROUND There have been conflicting reports on the use of intravenous administration of sodium bicarbonate for prevention of contrast-induced acute kidney injury (CI-AKI). The aim of this study was to evaluate the use of sodium bicarbonate for prevention of CI-AKI. METHODS This is a symptomatic review and meta-analysis of prospectively randomized studies, abstracts and manuscripts, publish...

Chronic kidney disease is an independent mortality and cardiovascular disease risk factor, often begins with some kidney damage initially asymptomatic, but as it progresses through the stages of CKD patients develop symptoms and complications of fluid overload, hypertension, hyperkalemia, metabolic acidosis, anemia, and mineral and bone disorders.Normal kidneys maintain acid-base balance by exc...

BACKGROUND Caffeine and sodium bicarbonate ingestion have been suggested to improve high-intensity intermittent exercise, but it is unclear if these ergogenic substances affect performance under provoked metabolic acidification. To study the effects of caffeine and sodium bicarbonate on intense intermittent exercise performance and metabolic markers under exercise-induced acidification, intense...

Background: Sodium bicarbonate serum therapy is used for compensation bicarbonate lost and increasing blood pH in metabolic acidosis caused by severe anemia in patient with glucose-6-phosphate dehydrogenase (G6PD) deficiency. The aim of present study was comparison the effect of serum therapy using two different serums (serum with bicarbonate and without bicarbonate) on some renal and hematolog...

BACKGROUND Optimal hydration measures to prevent contrast-induced nephropathy are controversial. STUDY DESIGN We conducted a systematic review and meta-analysis using the MEDLINE database (1966 to January 2008), EMBASE (January 2008), and abstracts from conference proceedings. SETTING & POPULATION Adult patients undergoing contrast procedures. SELECTION CRITERIA FOR STUDIES Randomized con...

Metabolic acidosis has recently been observed in rat models of salt-sensitive genetic hypertension. To test the hypothesis that salt sensitivity in humans may be associated with abnormal acid-base homeostasis, we performed arterial blood gas analyses in young (20-31 years old) normotensive subjects (n = 40) who were placed on a low salt diet (20 mmol NaCl/day) for 2 weeks with either 200 mmol s...

Isoji Sasagawa, MD, Department of Urology, Yamagata University, School of Medicine, 2-2-2 Iidanishi, Yamagata-shi, Yamagata 990-23 (Japan) pressure, bicarbonate and base excess. Sodium and potassium were determined by flame photometry. Chloride was measured by amperometric titration. BUN was determined by a diacetylmonoxime-thiosemicar-bizide reaction and creatinine was estimated with a modifie...

Because the use of phosphates has being recently diminished in meat industry due to the nutritional drawbacks of phosphates, some researchers started to evaluate sodium bicarbonate as phosphate replacer in meat products. The aim of this study was to evaluate the effect of different temperature combinations of dry air-cooking treatments (Air and Core temperatures: 160 76, 160 80, 200 76 and 200 ̊...

In situ perfusion of rat intestine was used to evaluate the effect of bicarbonate on the efficacy of a low sodium (35 mmol/l) glucose-electrolyte oral rehydration solution in normal and cholera toxin-treated rat small intestine. In normal intestine, absorption of water was greater (108 (8.1) microliters/min/g; p less than 0.01) and sodium secretion less (-4.3 (0.3) mumol/min/g; p less than 0.01...