Friend erythroleukemia cells can be induced to undergo erythroid differentiation by a variety of unrelated compounds. The fact that sodium butyrate causes reversible alterations in growth, morphology, and bio chemistry in many cell systems prompted us to reexamine its pattern of induction of differentiation and to compare it to that of dimethyl sulfoxide (DMSO) and hexamethylbisacetamide (HMBA)...

The pathogenesis and refractory nature of inflammatory bowel disease (IBD) are related to multiple factors, including genetic environmental abnormalities in gut microbial diversity, which lead decreased levels short-chain fatty acids (SCFAs). Among SCFAs, butyrate plays an important role mucosal barrier maintenance, serves as energy source intestinal epithelial cells (IECs), exhibits anti-infla...

In HL-60 cells, retinoic acid (RA) and 9 cis-RA induce granulocytic differentiation, and calcitriol and sodium butyrate induce monocytic differentiation. To study the role of retinoid resistance on the response to these agents, we investigated their effects in HL-60 cells, retinoid-resistant HL-60R cells, and HL-60R+ cells in which retinoid sensitivity has been restored. In HL-60 cells, catheps...

Sodium butyrate select ively Induces accumulation of metalIoth1onein-I (MT-I) RNA in H4IIE rat hepatoma ce l l s . The Induction 1s rap id; s igni f icant elevation 1n cytoplasnric MT-I RNA can be observed within three hours af ter exposure to 5 mM butyrate. Maximal levels of MT-I RNA are obtained af ter eight hours. Butyrate stimulates MT RNA accumulation 1n the absence of de_ novo protein syn...