Sodium polystyrene sulfonate (Kayexalate) and calcium polystyrene sulfonate (CPS, Kalimate) are commonly used to reduce serum potassium. There were some published evidences of severe gastrointestinal complications from the administration of these agents such as colonic necrosis with or without perforation and acute obstruction. The authors reported a 52-year-old male patient being critically il...

An alternating copolymer of styrene and maleic acid (alt-PSMA) differs from other polyanionic antiviral agents in that the negative charges of alt-PSMA are provided by carboxylic acid groups instead of sulfate or sulfonate moieties. We hypothesized that alt-PSMA would have activity against human immunodeficiency virus type 1 (HIV-1) comparable to other polyanions, such as the related compound, ...

The capillary electrophoretic behavior of 44 aromatic organic ions was investigated. The observed ionic radii (r(obs0)) for the aromatic organic ions were obtained from the electrophoretic mobilities of sodium tetraborate (pH 9.2), potassium tetraborate (pH 9.2), ammonium borate (pH 9.2), and trisodium phosphate (pH 11.7) buffers with zero ionic strength. The linear relationships between the r(...

Sodium-2-oxo-propanesulfonate (acetone sulfonate) was found to be a competitive inhibitor of acetoacetate carboxy lyase (acetoacetic decarboxylase, EC 4.1.1.4) the KI of which was numerically equal to the K, for acetoacetate at all temperatures investigated. K,,, like Kr in this case is therefore concluded to represent a dissociation constant. AH for the dissociation of either acetoacetate or a...

Sodium bisulfite reacts with cytosine and 5-methylcytosine, forming the 5,6-dihydrosulfonate adducts which deaminate to the uracil and thymine adducts, respectively. At alkaline pH, the sulfonate groups are then released, generating uracil and thymine. In DNA, the resulting G:U and G:T base mismatches generated are potential sites of mutagenesis. Using a human damage-specific DNA binding protei...

Sodium-2-oxo-propanesulfonate (acetone sulfonate) was found to be a competitive inhibitor of acetoacetate carboxy lyase (acetoacetic decarboxylase, EC 4.1.1.4) the KI of which was numerically equal to the K, for acetoacetate at all temperatures investigated. K,,, like Kr in this case is therefore concluded to represent a dissociation constant. AH for the dissociation of either acetoacetate or a...

Sodium dodecyl benzene sulfonate (SDBS), Polyvinylpyrrolidone (PVP, MW 10 kDa), and NaCl were obtained from Sigma Aldrich. Microcalorimetry experiments were performed using a MicorCal ITC-VP at the University of Albany Proteomics Facility in Rensselaer, NY. SDBS was added to de-ionized distilled water, and placed into the injection syringe of the microcalorimeter, and added to the sample cell c...

FEW QUANTITATIVE ANALYSES of cystine in human serum protein fractions have been recorded in the literature, since cystine cannot be determined easily by microbiologic assay or paper chromatography. Brand and his coworkers (1, 2, 3) have reported the amount of cystine and cysteine in a few protein fractions using phosphotungstate and iodometric methods, but few results have been given using the ...

Tanshinone IIA sodium sulfonate (TSS) is a water-soluble derivative of tanshinone IIA, which is the main pharmacologically active component of Salvia miltiorrhiza. This study aimed to verify the preventive and therapeutic effects of TSS and its combined therapeutic effects with magnesium isoglycyrrhizinate (MI) in D-galactosamine- (D-Gal-) induced acute liver injury (ALI) in mice. The potential...