Montmorillonite impregnated with bismuth nitrate has been found to be an excellent reagent for the synthesis of several nitro compounds of biological significance in high yield.

Heme oxygenase (HO) catalyzes the degradation of heme to form iron, biliverdin, and carbon monoxide (CO). The vascular actions of CO include direct vasodilation of vascular smooth muscle and indirect vasoconstriction through inhibition of nitric oxide synthase (NOS). This study was performed to examine the effects in the kidney of inhibition of heme oxygenase alone or combined with NOS inhibiti...

The present study was done to determine whether endogenous nitric oxide (NO) plays a role in the regulation of sodium transporters in the kidney. Male Sprague-Dawley rats were treated with NG-nitro-L-arginine methyl ester (L-NAME, 100 mg/L drinking water) for 4 weeks. Control rats were supplied with tap water without drugs. Expression of Na, K-ATPase, type 3 Na/H exchanger (NHE3), Na/K/2Cl cotr...

The kinetics of the degradation of the inhibitors of the nitric oxide synthesis, NG-nitro-L-arginine methyl ester and NG-nitro-L-arginine, were examined in human amniotic fluid and umbilical vein blood. The reaction rate constants were calculated or estimated using the time-controlled concentration course of both substances. These concentrations were measured by high-performance liquid chromato...

The redox chemistry of different nitro compounds of biological significance is focused to understand how the reduction of the nitro group can play an active role in several aspects as: electroanalytical determinations, free radical generation and stability and free radical reactivity. We have focused our studies to a lot of pharmaceuticals belonging mainly to the following families: calcium ant...