UNLABELLED Eisai hyperbilirubinemic rat (EHBR) is a mutant strain with a hereditary defect in canalicular multispecific organic anion transporter (cMOAT). We examined the uptake and mutual inhibition of S-(2,4-dinitrophenyl)-glutathione (DNP-SG), which is a typical substrate for cMOAT, and 6-hydroxy-5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl) benzothiazole (E3040) glucuronide (E-glu) with ca...

Hendra virus (HeV) and Nipah virus (NiV) are closely related emerging viruses comprising the Henipavirus genus of the Paramyxovirinae, which are distinguished by their ability to cause fatal disease in both animal and human hosts. These viruses infect cells by a pH-independent membrane fusion event mediated by their attachment (G) and fusion (F) glycoproteins. Previously, we reported on HeV- an...

Solid-state lasers are typically limited by adverse thermal effects within the gain medium. In this Letter we describe a new method for dramatically reducing thermal effects in an end-pumped solid-state laser by incorporating a rotating intracavity periscope in the resonator to spatially separate the lasing and thermal processes. In contrast with previous examples of moving solid-state lasers, ...

Based on the type of laser gain medium, lasers are mostly divided into four categories; gaseous, liquid (such as dye lasers), semiconductor, and solid state lasers. In recent past years, solid state lasers have been attracted considerable attentions in industry and scientific researches to achieve the high power laser devices with good beam quality. In solid state lasers the gain medium might b...

banana is one of the most important tropical fruit from commercial and industrial point of view. this fruit is an extremely perishable fruit which can not be preserved using freezing process. therefore, drying is the most promising method. conventional air drying is energy intensive and consequently expensive method. pre-treatments can be used to reduce the initial water content or to modify th...

Cytoplasmic stress granules (SGs) are multimolecular aggregates of stalled translation pre-initiation complexes that prevent the accumulation of misfolded proteins, and that are formed in response to certain types of stress including ER stress. SG formation contributes to cell survival not only by suppressing translation but also by sequestering some apoptosis regulatory factors. Because cells ...

Although the sebaceous gland (SG) plays an important role in skin function, the mechanisms regulating SG differentiation and carcinoma formation are poorly understood. We previously reported that c-MYC overexpression stimulates SG differentiation. We now demonstrate roles for the androgen receptor (AR) and p53. MYC-induced SG differentiation was reduced in mice lacking a functional AR. High lev...

In the present study, effects of sun ginseng (SG) on the collagen synthesis and the proliferation of dermal fibroblast were investigated. Collagen synthesis was measured by assaying procollagen type I C-peptide production. In addition, the level of matrix metalloproteinase (MMP)-1 was assessed by western blot analysis. SG suppressed the MMP-1 protein level in a dose-dependent manner. In contras...

Stress granules (SG) are dynamic cytoplasmic foci in which stalled translation initiation complexes accumulate. In conditions of acute cellular redox, stress cells manipulated to lose the expression of apoptosis-inducing factor (AIF) nucleate SG signature proteins (e.g. TIA-1, PABP1) more efficiently than AIF-positive controls. AIF also inhibited SG formation induced by the RasGAP-associated en...

We report on the experimental and theoretical studies of cooling field (HFC) and temperature (T) dependent exchange bias (EB) in FexAu1-x/Fe19Ni81 spin glass (SG)/ferromagnet (FM) bilayers. When x varies from 8% to 14% in the FexAu1-x SG alloys, with increasing T, a sign-changeable exchange bias field (HE) together with a unimodal distribution of coercivity (HC) are observed. Significantly, inc...