STATEMENT OF THE PROBLEM Structural integrity and dimensional stability are the key factors that determine the clinical success and durability of luting cements in the oral cavity. Sorption and solubility of self-adhesive resin luting cements in food-simulating solutions has not been studied sufficiently. PURPOSE This study aimed to compare the sorption and solubility of 2 conventional and 2 ...

A thermodynamic model for the solubility of carbon dioxide (CO2) in pure water and in aqueous NaCl solutions for temperatures from 273 to 533 K, for pressures from 0 to 2000 bar, and for ionic strength from 0 to 4.3 m is presented. The model is based on a specific particle interaction theory for the liquid phase and a highly accurate equation of state for the vapor phase. With this specific int...

Clopidogrel, an inhibitor of platelet aggregation, selectively inhibits the binding of adenosine diphosphate (ADP) to its platelet receptor and the subsequent ADP-mediated activation of the glycoprotein GPIIb/IIIa complex, thereby inhibiting platelet aggregation. Oral bioavailability of clopidogrel is very low (less than 50%), due to its poor water solubility. The aim of this investigation was ...

A phenomenological study of solubility has been conducted using a combination of quantitative structure-property relationship (QSPR) and principal component analysis (PCA). A solubility database of 4540 experimental data points was used that utilized available experimental data into a matrix of 154 solvents times 397 solutes. Methodology in which QSPR and PCA are combined was developed to predi...

Solubility and drug dissolution are of crucial importance for drug formulations. Poor water-solubility of drug candidates is a major obstacle in drug development, since the oral route is the most patient convenient and cost effective way to deliver drugs. In some cases the low aqueous solubility may limit the bioavailability when the absorption of the drug is dissolution limited. About 40% of t...

The extended Hildebrand solubility parameter approach is used to estimate the solubility of nabumetone in binary solvent systems. The solubility of nabumetone in various dioxane-water mixtures was analyzed in terms of solute-solvent interactions using a modified version of Hildebrand-Scatchard treatment for regular solutions. The solubility of nabumetone in the binary solvent, dioxane-water sho...

A novel method for thermodynamic stability studies of polymorphic drug substances has been developed. In order to estimate the transition temperature for an enantiotropic polymorphic pair, a formula for calculating the temperature at which the solubilities of each polymorph become equal has been derived with heat of solution and solubility as the variables. This formula is based on the assumpti...

Physico-chemical investigation of urolithiasis today is mostly focused on applying physico-chemical description of precipitation processes to the stone formation with the aim to distinguish between stone formers and nonstone formers. This is done by calculating supersaturation for different solid phases which can be formed in urine using data obtained by urine analysis and existing solubility p...