in this paper, we develop an inventory model for perishable items with random lifetime in a two-echelon production-distribution system. there is a manufacturer at the first stage that produces its product with a constant rate. deterioration in this stage is modeled via a two-parameter weibull distribution. at the second stage, the retailer places the order and receives the product instantly. th...

Low solubility compounds show dissolution rate limited absorption and hence poor absorption, distribution and target organ delivery. Improvement of aqueous solubility in such a case is valuable goal to improve therapeutic efficacy. Complexation with CDs by different methods like physical mixing, melting, kneding, spray drying, freeze drying, co-evaporation has been reported to enhance the solub...

This article is devoted to prove the basic Chen?s inequalities for slant submanifolds in Riemannian space forms equipped with Golden structure. The equality case and some particular cases of derived are discussed.

Aqueous solubility is a critical factor for optimum drug delivery. In the present study, we investigated the potential of drugcyclodextrin complexation as an approach for improving the solubility and bioavailability of famotidine, an H2-receptor antagonist and acid reducing drug which has poor solubility and bioavailability. Solubility improvement of drug by βcyclodextrin was done by simple com...

In this study, an experimental approach based on the isochoric pressure drop principle was implemented to measure (at low equilibrium pressure, 1.3–3.6 bar) solubility and binary diffusivity of CO2 (constant variable) in four imidazolium-based room-temperature ionic liquids (RTILs), namely, 1-ethyl-3-methylimidazolium acetate ([emim][Ac]), dicyanamide ([emim][DCA]), methyl sulfate ([emim][MeSO4...

Abstract In this paper, we study locally projectively flat Finsler metrics of constant flag curvature. We find equations that characterize these by warped product. Using the obtained equations, manufacture new product vanishing These contain metric introduced Berwald and spherically symmetric given Mo-Zhu.

A cobalt catalyst (25%Co/γ-Al2O3, prepared by slurry phase impregnation) was used in a fixed bed reactor under a pressure/density tuned supercritical fluid mixture of n-pentane/nhexane. By using an inert gas as a balancing gas to maintain a constant pressure, the density of the supercritical fluid could be tuned near the supercritical point while maintaining constant space velocity within the r...

Purpose: Lovastatin is poorly water soluble drug. It should be come into the BCS II drug. So oral bioavailability of lovastatin is less (50%). To develop novel dosage foam of the self-microemulsifying drug delivery systems (SMEDDS) for the lovastatin. Methods: Before the formulation of SMEDDS, solubility study was performed in different exicipients and select exicipients on basis of solubility ...