BACKGROUND Soluble endoglin, a TGF-β receptor, plays a key role in cardiovascular physiology. Whether circulating concentrations of soluble endoglin are elevated in CKD or underlie the high risk of cardiovascular death associated with chronic kidney disease (CKD) is unknown. METHODS Individuals with and without CKD were recruited at a single center. Estimated glomerular filtration rate (eGFR)...

In this study Response Surface Methodology was used to optimize process conditions and to evaluate the effect of ultrasound on quality attributes (antioxidant activity, pH, total soluble solid, turbidity) and the inactivation of Escherichia coli bacteria in carrot juice. Independent variables in this study were temperature (25-50°C), time (20-40 min) and frequency (0-130 kHz). In this study the...

Solid dispersions of a poorly water-soluble drug piroxicam in polyvinylpyrrolidone (PVP) were prepared by precipitation with compressed antisolvent (PCA) and spray drying techniques. Physicochemical properties of the products and drug-polymer interactions were characterized by powder X-ray diffraction, Fourier transform infrared spectroscopy, and differential scanning calorimetry, etc. Piroxica...

Oral drug delivery is considered as the most preferable route for chronic treatment of various diseases, due to its greater stability, flexibility in formulation, dosage accuracy, low cost of manufacturing and packaging and patient friendly administration [1]. But most of the drugs belong to poorly water soluble (BCS Class II) category and suffering from poor dissolution and it is worst if give...

Studies of soluble small-molecule semiconductors based on pentacene and anthradithiophene chromophores have generally shown that molecules with strong two-dimensional solid-state interactions yield high-performance thin-film transistors, while similar compounds with onedimensional solid-state interactions form thin-film devices with significantly worse performance. As a further exploration of t...

Naproxen is a poor water soluble, non-steroidal analgesic and anti-inflammatory drug. The enhancement of oral bioavailability of poor water soluble drugs remains one of the most challenging aspects of drug development. Although salt formation, solubilization and particle size reduction have commonly been used to increase dissolution rate and thereby oral absorption and bioavailability of low wa...

Solid dispersions are a useful approach to improve the dissolution rate and bioavailability of poorly water-soluble active pharmaceutical ingredients (APIs). The aim of this study was to improve the physicochemical properties and bioavailability of a poorly water-soluble aprepitant by preparation of solid dispersions. The solid dispersions were characterized by dissolution, FTIR, XRPD, DSC, SEM...

Solid dispersions traditionally have been used as effective methods to improve the dissolution properties and bioavailability of poorly water-soluble drugs. Furosemide a loop diuretic belonging to Biopharmaceutical Classification System (BCS) Class IV, has very poor water solubility. The aim of the present study was to improve the solubility and dissolution rate of a poorly water-soluble drug, ...