been detected in central nervous system of rodents, nonhuman primates and human based on radioligand binding studies. KOR agonists may have pharmacotherapeutic potential in the treatment of pain or hyperalgesia and in the management of psychostimulant addiction. However, the clinical application of selective KOR agonists, such as ethylketocyclazocine and U-50488, has been limited by the occurre...

A broadband reflector with a reflectance up to 97.8% over 144 nm spectral range from 1476 1620 is proposed by comprising double-layer subwavelength gratings one grating layer embedded in SiO2 layer. An analysis of the resonance leaky modes overlapping shows physical mechanism wide broad high-reflectivity band. The tolerance structural parameter analyzed and variation bandwidth explained combini...

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We describe an ultramicromethod for measurement of terminal deoxynucleotidyl transferase activity. The materials used are as proposed by Hösli (Clin Chem 1977;23:1476-84) for antenatal diagnosis. The technique is based on the methods of Beutler and Kuhl (Am J Clin Pathol 1978;70:733-7) and Yasmineh et al. (Clin Chem 1980; 26:891-5). The procedure makes it possible to reduce the blood sample to ...