Integrin-mediated adhesion plays an important role in B cell development and activation. Signaling initiated by antigens, chemokines, or phorbol esters can rapidly convert integrins to an activated adhesion-competent state. The binding of integrins to their ligands can then induce actin-dependent cell spreading, which can facilitate cell-cell adhesion or cell migration on extracellular matrices...

Titin (also known as connectin) is a giant protein that spans half of the striated muscle sarcomere. In the I-band titin extends as the sarcomere is stretched, developing what is known as passive force. The I-band region of titin contains tandem Ig segments (consisting of serially linked immunoglobulin-like domains) with the unique PEVK segment in between (Labeit, S., and B. Kolmerer. 1995. Sci...

We explored mechanisms involved in B cell self-tolerance against brain autoantigens in a double-transgenic mouse model carrying the Ig H-chain (introduced by gene replacement) and/or the L-chain kappa (conventional transgenic) of the mAb 8.18C5, specific for the myelin oligodendrocyte glycoprotein (MOG). Previously, we demonstrated that B cells expressing solely the MOG-specific Ig H-chain diff...

Long-term (chronic) allotype suppression, previously reported only in rabbits, is shown here to occur in at least one strain combination of mice as well. Close to 50% of the offspring of SJL (Ig(b)) males mated to BALB/c (Ig(a)) females immunized against the paternal allotype were found to be suppressed for Ig-1b (gammaG(2a)) at 6 months of age. These mice are called "chronically" suppressed. T...

B Y R E A D IN G T H S F O L L O W IN G A F F ID A V IT — th e P u b lic w ill le a rn xno o rig in , o r r a th e r w b e ro th e rec ip e fn r m a k in g th e s tu ff th e y c a ll O ld 'D r . J a c o b T ow nsend '* S a rs a p a ril la , crim e fro m —and w ill bo a b le to ju d g e w h ic h ia -.e g e n u in e and o r ig in a l, and o f th e h o n es ty o f th e m en w h o a r c e m p lo y ...

The St. Joseph Circuit Court issued an injunction Tuesday a g a in s t e ig h t r e s i d e n t s of Wooded E s ta te s , p ro h ib i t in g them from c h a r g in g fan s to park vehicles on their property during Notre Dame home foot­ ball games. According to the injunction, such behavior qualifies as com­ mercial activity on residential property, violating Section 21-8 of the city code, along...

A large number of CD4 + human T helper type 1 (Thl) clones specific for purified protein derivative and of Th2 clones specific for the excretory/secretory antigen of Toxocara canis, derived from the same individuals, were analyzed for both cytotoxic capacity and helper function for immunoglobulin (Ig) synthesis. The great majority of Thl, but only a minority of Th2 clones exhibited cytolytic ac...

Objective: We present a statistical model for extracting physiologic characteristics from electrodermal activity (EDA) data in observational settings. Methods: based our on the integrate-and-fire physiology of sweat gland bursts, which predicts inverse Gaussian (IG) inter-pulse interval structure. At core model-based paradigm is subject-specific amplitude threshold selection process EDA pulses ...

The prostatic fluid of two patients with Escherichia coli bacterial prostatitis was analyzed for evidence of a local immune response to bacterial infection. A solid-phase radioimmunoassay was modified to measure the immunoglobulin (Ig)A and IgG antigen-specific antibody responses to infecting bacteria in serum and prostatic fluid from patient. Formalin-fixed whole E. coli were used as antigen. ...