نتایج جستجو برای: specific phenotype
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OBJECTIVE To increase power to detect modifier loci conferring susceptibility to specific phenotypes such as disease diagnoses which are part of a broader disorder spectrum by jointly modeling a modifier and a broad susceptibility gene and to identify modifier loci conferring specific susceptibility to schizophrenia (SZ) or to bipolar disorder (BP) using the approach. METHODS We implemented a...
Rhizobia represent a diverse group of gram-negative bacteria capable fixing atmospheric nitrogen in symbiosis with leguminous plants. Mechanisms symbiotic efficiency are important to study not only reveal the “fine tuning” host–symbiont supra-organismal genetic system emergence, but also develop agriculture minimal environmental risks. In this paper we demonstrate that among seven genes whose i...
Myocyte enhancement factor 2C (MEF2C) is a transcription studied in the development of skeletal and smooth muscles. Bone resorption studies have exhibited that reduced expression MEF2C contributes to osteopetrosis dysregulation pathological bone remodeling. Our current study aims determine how osteoclast differentiation analyze phenotype Mef2c-cKO mice (Cfms-cre; Mef2cfl/fl). qRT-PCR Western bl...
Phenotype-Specific Enrichment of Mendelian Disorder Genes near GWAS Regions across 62 Complex Traits
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