A 73-year-old man with aortic regurgitation was examined by 123I-alpha-methyl-p-iodophenylpentadecanoic acid (BMIPP) myocardial single photon emission computed tomography (SPECT) in 1995. Myocardial accumulation was not evident on either the early or the delayed image obtained 15 minutes and 3 hours, respectively, after injecting 123I-BMIPP. Flow cytometric analysis of CD36 expression in monocy...

introduction: scattered photon is one of the main defects that degrade the quality and quantitative accuracy of nuclear medicine images. accurate estimation of scatter in projection data of spect is computationally extremely demanding for activity distribution in uniform and non-uniform dense media. methods: the objective of this paper is to develop and validate a scatter correction technique ...

OBJECTIVE The aim of this study was to investigate the registration accuracy of a newly developed patient shuttle system that can integrate different scanners by patient transfer without repositioning for 'hardware'-based image fusion. We aimed to assess the registration accuracy of image fusion in two different settings: a trimodality PET/CT+MR system and a SPECT+CT system. MATERIALS AND MET...

Background: Real cardiac phantoms are often used to assess the performance of software for gated single-photon emission computed tomography(SPECT). However, these phantoms have disadvantages in that they are not very similar to actual hearts and setting a perfusion defect is not easy. To overcome these problems, we developed a digital myocardial phantom, named%Myo-Simu'. The aims of this study ...

BACKGROUND Dyspnea is a complex system with multiple etiologies, including myocardial ischemia ("anginal equivalent"). Few studies have examined the utility of stress testing to detect coronary artery disease in this setting. The purpose of this study was to examine the prevalence, severity, and prognostic value of perfusion defects detected by stress single photon emission computed tomography ...

  Objective(s): In SPECT, the sinogram contains scatter and lack of attenuated counts that degrade the reconstructed image quality and quantity. Many techniques for attenuation and scatter correction have been proposed. An acceptable method of correction is to incorporate effects into an iterative statistical reconstruction. Here, we propose new Maximum Likelihood Expectation Maximiz...

UNLABELLED Our objective was to optimize the quality of (123)I-metaiodobenzylguanidine (MIBG) scans by using a medium-energy collimator to reduce high-energy-photon septal penetration. METHODS In addition to the 159-keV γ-ray, (123)I has a small abundance of energies above 400 keV that can compromise the image quality of MIBG studies because of septal penetration. Using a low-energy ultrahigh...

UNLABELLED Gated SPECT recorded with 16 intervals determines left ventricular (LV) ejection fraction more accurately than does gated SPECT recorded with 8 intervals but produces higher image noise. This study aimed to assess the results from sestamibi and (201)Tl 16-interval gated SPECT when both signal-to-noise ratio and spatial resolution were enhanced with an original method of reconstructio...

PURPOSE To describe our approach to mapping the functional information provided by single photon emission computed tomography (SPECT) onto the anatomic template provided by MR, and to determine both the number of markers required to achieve accuracy and the impact of voxel shape on accuracy. METHODS Point-to-point iterative minimization using externally fixed fiducial markers was involved and...

BACKGROUND Assessment of liver function is critical in hepatocellular carcinoma (HCC) patient management. We evaluated parameters of [(99m)Tc] sulfur colloid (SC) SPECT/CT liver uptake for association with clinical measures of liver function and outcome in HCC patients. METHODS Thirty patients with HCC and variable Child-Turcotte-Pugh scores (CTP A5-C10) underwent [(99m)Tc]SC SPECT/CT scans f...