BACKGROUND & OBJECTIVES Nestin is an intermediate filament protein expressed in undifferentiated cells during the development of brain and is considered as a marker for neuroepithelial stem cells. Expression of this protein in various CNS tumour cells suggests the possibility of existence of tumour stem cell modulating the evolution. We carried out an immunohistochemical study to demonstrate th...

In forty-two cases of tumours of the glioma group giving rise to metastases, Polmeteer and Kernohan (1947) found only one pinealoma. In this case, which is recorded in detail by Bagenstoss and Love (1939), the tumour filled the third ventricle and had become implanted in the other ventricles and on the roots of most of the cranial nerves. The spinal cord was not examined. These authors also des...

Giomas constitute a broad class of neuroectodermal tumours believed to originate from sustentacular neuroglial cells (Kleihues and Cavenee 2000). Astrocytomas form the largest group of gliomas (>75%) and glioblastoma multiforme (GBM) is the most common type of astrocytoma (CBTRUS 2011). Gliomas that share histologic characteristics with ependymal or oligodendrocyte cells are named ependymomas a...

©2005 British Editorial Society of Bone and Joint Surgery doi:10.1302/0301-620X.87B8. 16151 $2.00 J Bone Joint Surg [Br] 2005;87-B:1029-37. Rationale for total lumbar disc replacement In the early 20th century, surgical fusion of one or more ‘functional spinal units’ (FSU) was developed and primarily performed for the treatment of spinal infection. 1-4 In the second half of the century, the ind...

the rectum villous tumour is an uncommon pathology in paediatrics, it represent 1% of all the children's malign tumours. an eleven-year-old girl present a rectal adenocarcinoma developed from a villous tumour. the aim of this study is to assess , an overview of litterature, the frequency of rectum villous tumours; to specify the value of the clinical examination , of the radiologic finding in t...

Most metastatic spinal lesions (70%) are found at the thoracic level, 20% in the lumbar region, and 10% in the cervical region. A variety of benign and malignant tumours may arise in the lung, but the vast majority is bronchogenic carcinomas (90 to 95%). The aim of this study was to evaluate the lung cancer metastases to the vertebral column in terms of type, localisation and metastasis pattern...

BACKGROUND: Tumours form an integral part of disease process affecting the CNS and constitute a major part of all intracranial space occupying lesions. AIM: To study the histological findings of CNS tumors and to classify them according to WHO classification. MATERIALS AND METHODS: This is a five year study in which all the specimens of tumors of brain and spinal cord received in the department...

BACKGROUND Patients with metastatic spinal tumours have a limited prognosis. Surgical complications that may result in prolonged hospitalization or readmission are highly undesirable. Surgical site infection (SSI) is one such complication, which can, in extreme cases, lead to death. AIM To assess the impact of SSI on patient survival after surgery for spinal metastases. METHODS Demographic,...