Recently it has become apparent that there is a tendency for penicillin to fail in the treatment of gonorrhoea (Curtis and Wilkinson, 1958; King, 1958; Willcox, 1959). This would appear to be due to the development of resistance on the part of the gonococcus. It was decided to compare the effect in vivo of two new antibiotics using two series treated with penicillin as controls. In one control ...

Numerous workers in many countries (Willcox, 1961) have reported increasing failure rates in the treatment of gonorrhoea both with penicillin and with streptomycin (Alergant, 1958). Evidence is accumulating of an increased number of strains of gonococci which are less sensitive to these antibiotics than formerly (Cradock-Watson, Shooter, and Nicol, 1958; Curtis and Wilkinson, 1958). Although "r...

Linezolid, the first oxazolidinone to be used clinically, is effective in the treatment of infections caused by various Gram-positive pathogens, including multidrug resistant enterococci and methicillin-resistant Staphylococus aureus. It has been used successfully for the treatment of patients with endocarditis and bacteraemia, osteomyelitis, joint infections and tuberculosis and it is often us...

Pharmaceuticals and personal care products (PPCPs) were investigated in five wastewater treatment plants (WWTPs), groundwater, irrigated soils, Amman Al-Balqa governorates Jordan. PPCPs extracted from water samples by solid-phase extraction (SPE) analyzed high-performance liquid chromatography coupled with tandem mass spectrometry (HPLC–MS/MS). Carbamazepine, ciprofloxacin, ceftiofur, diclofena...

Pristinamycin is a synergistic combination of streptogramin A (pristinamycin IIA) and streptogramin B (pristinamycin IB) compounds, licensed in France and some other European countries. This oral antibiotic has been considered as an alternative treatment for infections due to penicillinand macrolide-resistant Streptococcus pneumoniae because streptogramins remain active against streptococci and...