interference with microtubule polymerization results in cell cycle arrest leading to cell death. colchicine is a well-known microtubule polymerization inhibitor which does so by binding to a specific site on tubulin. a set of 3',4'-bis (substituted phenyl)-4'h-spiro[indene-2,5'-isoxazol]-1(3h)-one derivatives with known antiproliferative activities were evaluated for their t...

Femtosecond Raman spectroscopy has been developed to investigate ultrafast photoinduced structural changes of materials. Vibrational modes in the photogenerated transient species are measured by stimulated Raman scattering using a Raman pump pulse with narrow bandwidth and a femtosecond supercontinuum probe pulse. The Raman signal can be measured without slowing the temporal response and broade...

The energy relay dye, 4-(Dicyanomethylene)-2-methyl-6-(4-dimethylaminostyryl)-4H-pyran (DCM), was used with a near-infrared sensitizing dye, TT1, to increase the overall power conversion efficiency of a dye-sensitized solar cell (DSC) from 3.5% to 4.5%. The unattached DCM dyes exhibit an average excitation transfer efficiency (ETE) of 96% inside TT1-covered, mesostructured TiO(2) films. Further...

We report an organic solid-state distributed feedback laser consisting of an organic active layer and a Bragg grating without morphological change. The active layer consists of 4-~dicyanomethylene!-2-methyl-6-~4-dimethylaminostryl!-4H-pyran as a laser dye, tris~8hydroxyquinoline! aluminum as a host, and poly~methyl methacrylate! as a binder. The threshold and linewidth of the laser are 400 mJ/c...

The title compound, C(19)H(18)O(7) [systematic name 5-hy-droxy-3,6,7-tri-meth--oxy-2-(4-meth-oxy-phen-yl)-4H-1-benzopyran-4-one], is a flavonoid which was isolated from the traditional Chinese medicine Laggera alata. The benzene ring of the benzopyran-one unit forms dihedral angles of 1.72 (3) and 37.39 (5)° with the pyran ring and the substituent benzene ring, respectively. The mol-ecular conf...

In the title compound, C21H16N2O2, the meth-oxy-benzene ring is almost perpendicular to the mean plane of the naphthalene ring system, making a dihedral angle of 83.62 (5)°. The 4H-pyran ring fused with the naphthalene ring system is almost planar [maximum deviation = 0.033 (1) Å]. In the crystal, mol-ecules are linked into inversion dimers by pairs of N-H⋯N hydrogen bonds. N-H⋯O hydrogen bonds...

ABSTRACT A magnetic nanoparticle supported hyperbranched polyglycerol catalyst was prepared readily from inexpensive starting materials in aqueous medium that catalyzed the synthesis of 4H-benzo[b]pyran under solvent-free conditions at room temperature. X-ray diffraction, transmission electron microscopy, thermal gravimetric analysis, vibrating sample magnetometry, and selected-area electron di...

Isoflavone, Biochanin A, Dihydrobiochanin A, Phenylacetic acids, Fusarium javanicum After a lag-phase of 1 h a mycelial suspension of Fusarium javanicum completely degraded 5,7-dihydroxy-4'-methoxyisoflavone (biochanin A) to a series of transiently accumulating catabolites. The compounds were elucidated by spectroscopic techniques and are arranged in the first known degradative pathway for an i...